Thyroid hormones and cardiac arrhythmias

被引：59

作者：

Tribulova, Narcis ^{[1
]}

Knezl, Vladimir ^{[2
]}

Shainberg, Asher ^{[3
]}

Seki, Shingo ^{[4
]}

Soukup, Tomas ^{[5
]}

机构：

[1] Slovak Acad Sci, Heart Res Inst, Dubravska Cesta 9,POB 104, Bratislava 84005, Slovakia

[2] Slovak Acad Sci, Inst Expt Pharmacol & Toxicol, Bratislava 84005, Slovakia

[3] Bar Ilan Univ, Fac Life Sci, Ramat Gan, Israel

[4] Jikei Univ, Dept Internal Med, Div Cardiol, Tokyo, Japan

[5] Acad Sci Czech Republ, Inst Physiol, Prague, Czech Republic

来源：

VASCULAR PHARMACOLOGY | 2010年 / 52卷 / 3-4期

关键词：

Thyroid hormone; Arrhythmias; Ion channels; Connexin-43; Ca2+ handling; PROTEIN-KINASE-C; ATRIAL-FIBRILLATION; VENTRICULAR-FIBRILLATION; GENE-EXPRESSION; RISK-FACTOR; SUBCLINICAL HYPERTHYROIDISM; MYOCARDIAL-INFARCTION; EPSILON EXPRESSION; POTASSIUM CHANNELS; CALCIUM OVERLOAD;

D O I：

10.1016/j.vph.2009.10.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Thyroid hormone plays an important role in cardiac electrophysiology and Ca2+ handling through both genomic and nongenomic mechanisms of action, while both actions can interfere. Chronic changes in the amount of circulating thyroid hormone due to thyroid dysfunction or systemic disease result in structural, electrophysiological and Ca2+ handling remodeling, while acute changes may affect basal activity of cardiac cells membrane systems. Consequently, long-term or rapid modulation of sarcolemmal ion channels, Ca2+ cycling proteins and intercellular communicating channels by thyroid hormone may affect heart function as well as susceptibility of the heart to arrhythmias. This aspect including pro- and anti-arrhythmic potential of thyroid hormone is highlighted in this review. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：102 / 112

页数：11

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