Nanoceria: a Potential Therapeutic for Dry AMD

被引：20
作者：
Cai, Xue [1 ]
McGinnis, James F. [1 ,2 ]
机构：
[1] Univ Oklahoma, Hlth Sci Ctr, Dept Ophthalmol, Dean McGee Eye Inst, 608 Stanton L Young Blvd, Oklahoma City, OK 73104 USA
[2] Univ Oklahoma, Hlth Sci Ctr, Dept Ophthalmol, Dean McGee Eye Inst,Dept Cell Biol,Oklahoma Ctr N, Oklahoma City, OK 73104 USA
来源：
RETINAL DEGENERATIVE DISEASES: MECHANISMS AND EXPERIMENTAL THERAPY | 2016年 / 854卷
关键词：
Dry AMD; Drusen; RPE; Animal models; Therapeutic strategies; Nanoceria; RETINAL-PIGMENT EPITHELIUM; MACULAR DEGENERATION; INTRAVITREAL INJECTION; GEOGRAPHIC ATROPHY; TUBBY MICE; ACTIVATION; AUTOPHAGY; MODEL; NANOPARTICLES; PROTECTION;
D O I：
10.1007/978-3-319-17121-0_16
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Age-related macular degeneration (AMD) is the leading cause of blinding diseases. The "dry" form of AMD is the most common form of AMD. In contrast to the treatable neovascular (wet) AMD, no effective treatment is available for dry AMD. In this review, we summarize the animal models and therapeutic strategies for dry AMD. The novel candidates as potential treatment targets and the potential effectiveness of nanoceria as a treatment of dry AMD are also discussed.
引用
收藏
页码：111 / 118
页数：8
相关论文
共 36 条
[21]   Nanoceria extend photoreceptor cell lifespan in tubby mice by modulation of apoptosis/survival signaling pathways [J].
Kong, Li ;
Cai, Xue ;
Zhou, Xiaohong ;
Wong, Lily L. ;
Karakoti, Ajay S. ;
Seal, Sudipta ;
McGinnis, James F. .
NEUROBIOLOGY OF DISEASE, 2011, 42 (03) :514-523
[22]   INVESTIGATION OF ORAL FENRETINIDE FOR TREATMENT OF GEOGRAPHIC ATROPHY IN AGE-RELATED MACULAR DEGENERATION [J].
Mata, Nathan L. ;
Lichter, Jay B. ;
Vogel, Roger ;
Han, Yun ;
Bui, Tam V. ;
Singerman, Lawrence J. .
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 2013, 33 (03) :498-507
[23]   Distribution of Hyperpolarized Xenon in the Brain Following Sensory Stimulation: Preliminary MRI Findings [J].
Mazzanti, Mary L. ;
Walvick, Ronn P. ;
Zhou, Xin ;
Sun, Yanping ;
Shah, Niral ;
Mansour, Joey ;
Gereige, Jessica ;
Albert, Mitchell S. .
PLOS ONE, 2011, 6 (07)
[24]   Stem cells: a new paradigm for disease modeling and developing therapies for age-related macular degeneration [J].
Melville, Heather ;
Carpiniello, Matthew ;
Hollis, Kia ;
Staffaroni, Andrew ;
Golestaneh, Nady .
JOURNAL OF TRANSLATIONAL MEDICINE, 2013, 11
[25]   Animal models of age related macular degeneration [J].
Pennesi, Mark E. ;
Neuringer, Martha ;
Courtney, Robert J. .
MOLECULAR ASPECTS OF MEDICINE, 2012, 33 (04) :487-509
[26]   Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD) [J].
Ramkumar, Hema L. ;
Zhang, Jun ;
Chan, Chi-Chao .
PROGRESS IN RETINAL AND EYE RESEARCH, 2010, 29 (03) :169-190
[27]   CNTF-mediated protection of photoreceptors requires initial activation of the cytokine receptor gp130 in Muller glial cells [J].
Rhee, Kun Do ;
Nusinowitz, Steven ;
Chao, Kevin ;
Yu, Fei ;
Bok, Dean ;
Yang, Xian-Jie .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (47) :E4520-E4529
[28]   Dry Age-Related Macular Degeneration: Mechanisms, Therapeutic Targets, and Imaging [J].
Rickman, Catherine Bowes ;
Farsiu, Sina ;
Toth, Cynthia A. ;
Klingeborn, Mikael .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2013, 54 (14) :ORSF68-ORSF80
[29]   Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells [J].
Ryhanen, Tuomas ;
Hyttinen, Juha M. T. ;
Kopitz, Juergen ;
Rilla, Kirsi ;
Kuusisto, Erkki ;
Mannermaa, Eliisa ;
Viiri, Johanna ;
Holmberg, Carina I. ;
Immonen, Ilkka ;
Meri, Seppo ;
Parkkinen, Jussi ;
Eskelinen, Eeva-Liisa ;
Uusitalo, Hannu ;
Salminen, Antero ;
Kaarniranta, Kai .
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2009, 13 (9B) :3616-3631
[30]   Embryonic stem cell trials for macular degeneration: a preliminary report [J].
Schwartz, Steven D. ;
Hubschman, Jean-Pierre ;
Heilwell, Gad ;
Franco-Cardenas, Valentina ;
Pan, Carolyn K. ;
Ostrick, Rosaleen M. ;
Mickunas, Edmund ;
Gay, Roger ;
Klimanskaya, Irina ;
Lanza, Robert .
LANCET, 2012, 379 (9817) :713-720
1234