Simplification and improvement of height-based azithromycin treatment for paediatric trachoma

被引:23
作者
Basilion, EV
Kilima, PM
Mecaskey, JW
机构
[1] Int Trachoma Initiat, New York, NY 10017 USA
[2] Int Trachoma Initiat, Dar Es Salaam, Tanzania
关键词
trachoma; azithromcyin; community-based programme; height schedule; children;
D O I
10.1016/j.trstmh.2004.01.014
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Recent data showing that azithromycin is safe at higher dosages than previously documented provide an opportunity to explore several important improvements in the efficiency and effectiveness of height-based treatment of paediatric trachoma. The purpose of this study is to examine the feasibility of a single standardised schedule for application in any trachoma-endemic region. Data for 60813 children from Asia, North and sub-Saharan Africa were analysed. A height schedule maximizing the number of children receiving treatment of 20-40 mg/kg, a conservative estimate of the safe and effective treatment range for paediatric trachoma, was developed. Using the standardised schedule, 97.7% of children aged 6 to 59 months receiving oral suspension and 96.7% of children aged 60 months to 15 years receiving tablets would have received treatment within a dosage range of 20-40 mg/kg. Less than 1% of all children would have received treatment less than 20 mg/kg. These findings suggest that the schedule presented in this paper is likely to yield safe and effective treatment for a broad range of populations vulnerable to trachoma white substantially improving the efficiency of height-based treatment. (C) 2004 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:6 / 12
页数:7
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