Silkworm dropping extract regulates food allergy symptoms via inhibition of Th2-related responses in an ovalbumin-induced food allergy model

被引:8
作者
Jung, Sun Young [1 ,2 ]
See, Hye-Joeng [1 ]
Kwon, Da-Ae [1 ]
Choi, Dae-Woon [1 ,2 ]
Lee, So-Young [1 ,2 ]
Shon, Dong-Hwa [1 ,3 ]
Shin, Hee Soon [1 ,2 ]
机构
[1] Korea Food Res Inst, Div Nutr & Metab Res, 245 Nongsaengmyeong Ro, Wanju Gun 55365, Jeollabuk Do, South Korea
[2] Korea Univ Sci & Technol, Food Biotechnol Program, Daejeon, South Korea
[3] Gangneung Wonju Natl Univ, Dept Food Proc & Distribut, Kangnung, Gangwon Do, South Korea
关键词
silkworm dropping; food allergy; immunoglobulin E; Th2-related cytokines; SCUTELLARIA-BAICALENSIS EXTRACT; ANTIGEN-INDUCED DEGRANULATION; INTESTINAL BARRIER FUNCTION; TNF-ALPHA; STRUCTURAL REQUIREMENTS; ANTIALLERGIC ACTIVITY; MOUSE MODEL; RELEASE; CELLS; IL-4;
D O I
10.1002/jsfa.9993
中图分类号
S [农业科学];
学科分类号
09 ;
摘要
BACKGROUND Silkworm droppings have long been used in traditional medicine to remedy allergic itching, palsy, blood circulation problems, and arthritis in Asian countries. To investigate the anti-allergic effect of silkworm dropping extract (SDE) and its mechanism, we used a mouse model of food allergy induced by ovalbumin (OVA). RESULTS SDE ameliorated the symptoms of OVA-induced food allergies, and the levels of T helper 2 (Th2)-related cytokines [such as interleukin (IL)-4, IL-5, IL-10, and IL-13] were found to be significantly decreased in both the spleen and mesenteric lymph nodes by SDE. Furthermore, SDE treatment directly inhibited OVA permeation, IL-4 production, and degranulation of mast cells; in contrast, immunoglobulin E (IgE) production from B cells was not affected. CONCLUSION These results suggest that SDE has potential anti-allergic activities, and SDE may be useful in the treatment/prevention of allergic disorders such as food allergies, serving as therapeutic agents. (c) 2019 Society of Chemical Industry
引用
收藏
页码:7008 / 7015
页数:8
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