Vitamin D and calcium intakes and breast cancer risk in pre- and postmenopausal women

被引:58
作者
Anderson, Laura N. [1 ,2 ]
Cotterchio, Michelle [1 ,2 ]
Vieth, Reinhold [3 ]
Knight, Julia A. [2 ,4 ]
机构
[1] Canc Care Ontario, Populat Studies & Surveillance, Toronto, ON M5G 2L7, Canada
[2] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada
[3] Mt Sinai Hosp, Dept Pathol & Lab Med, Toronto, ON M5G 1X5, Canada
[4] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Prosserman Ctr Hlth Res, Toronto, ON M5G 1X5, Canada
基金
加拿大健康研究院;
关键词
PLASMA 25-HYDROXYVITAMIN D; PROSPECTIVE COHORT; ADOLESCENT DIET; DAIRY-PRODUCTS; PREVENTION; EXPOSURE; ASSOCIATION; 1,25-DIHYDROXYVITAMIN-D; SUPPLEMENTATION; QUESTIONNAIRE;
D O I
10.3945/ajcn.2009.28869
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Some evidence suggests that vitamin D may reduce breast cancer risk. Despite the biological interaction between vitamin D and calcium, few studies have evaluated their joint effects on breast cancer risk. Objective: The objective was to evaluate the associations and potential interaction between vitamin D and calcium (from food and supplements) and breast cancer risk in a population-based case-control study. Design: Breast cancer cases aged 25-74 y (diagnosed 2002-2003) were identified through the Ontario Cancer Registry. Controls were identified by using random digit dialing; 3101 cases and 3471 controls completed epidemiologic and food-frequency questionnaires. Adjusted odds ratios (ORs) and 95% CIs were estimated by using multivariate logistic regression. Results: Vitamin D and calcium intakes from food only and total combined intakes (food and supplements) were not associated with breast cancer risk, although the mean intake of vitamin D was low. Vitamin D supplement intake >10 mu g/d (400 IU/d) compared with no intake was associated with a reduced risk of breast cancer (adjusted OR: 0.76; 95% CI: 0.59, 0.98). No categories of calcium supplement intake were significantly associated with reduced breast cancer risk, but a significant inverse trend was observed (P = 0.04). There were no significant interactions involving vitamin D, calcium, or menopausal status. Conclusions: No associations were found between overall vitamin D or calcium intake and breast cancer risk. Vitamin D from supplements was independently associated with reduced breast cancer risk. Further research is needed to investigate the effects of higher closes of vitamin D and calcium supplements. Am J Clin Nutr 2010;91:1699-707.
引用
收藏
页码:1699 / 1707
页数:9
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