Prediction of Clinical Outcome in Locally Advanced Non-Small Cell Lung Cancer Patients Treated With Chemoradiotherapy by Plasma Markers

被引：9

作者：

Sui, Xin ^{[1
]}

Jiang, Leilei ^{[1
]}

Teng, Huajing ^{[1
]}

Mi, Lan ^{[2
]}

Li, Bo ^{[1
]}

Shi, Anhui ^{[1
]}

Yu, Rong ^{[1
]}

Li, Dongming ^{[1
]}

Dong, Xin ^{[1
]}

Yang, Dan ^{[1
]}

Yu, Huiming ^{[1
]}

Wang, Weihu ^{[1
]}

机构：

[1] Peking Univ Canc Hosp & Inst, Dept Radiat Oncol, Minist Educ Beijing, Key Lab Carcinogenesis & Translat Res, Beijing, Peoples R China

[2] Peking Univ Canc Hosp & Inst, Dept Lymphoma, Minist Educ Beijing, Key Lab Carcinogenesis & Translat Res, Beijing, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2021年 / 10卷

基金：

中国国家自然科学基金;

关键词：

non-small cell lung cancer; chemoradiotherapy; cytokines; IL-8; intercellular adhesion molecule 1 (ICAM-1); biomarkers; SURVIVAL; RADIOTHERAPY;

D O I：

10.3389/fonc.2020.625911

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose To identify cytokines in plasma that may predict objective response and progression-free survival (PFS) in patients with locally advanced non-small cell lung cancer (NSCLC) treated with chemoradiotherapy. Materials and Methods From April 2016 to May 2017, thirty-one patients with locally advanced inoperable/unresectable NSCLC were included, and treated with concurrent chemoradiotherapy (CCRT). No immune checkpoint inhibitors were administered after CCRT. Plasma from each patient was collected before radiotherapy, and 25 cytokines in the plasma were measured by Luminex or U-PLEX assays. Logistic regression and COX regression were performed to identify the predictive factors for objective response and PFS, respectively. Kaplan-Meier survival analysis was used to compare the PFS between the groups. Results High levels of IL-13 and TNF-alpha, and low levels of ICAM-1, IFN-gamma, and soluble PD-L1 (sPD-L1) were significantly associated with objective response (P <0.05). High levels of IL-8, CCL5, and CXCL3 also showed a trend toward association with objective response (P <0.1). The combination of cytokines (IL-8 and ICAM-1, or TNF-alpha and sPD-L1) improved predictive accuracy. Univariate analysis identified IL-8 and ICAM-1 as potential markers to predict PFS. Multivariate analysis suggested that high level of IL-8 (P =0.010) and low level of ICAM-1 (P =0.011) correlated significantly with a longer PFS. Conclusion IL-8 and ICAM-1 in plasma have the potential to predict objective response and PFS in patients with locally advanced NSCLC underwent chemoradiotherapy.

引用

页数：8