Prediction of Clinical Outcome in Locally Advanced Non-Small Cell Lung Cancer Patients Treated With Chemoradiotherapy by Plasma Markers

被引:9
作者
Sui, Xin [1 ]
Jiang, Leilei [1 ]
Teng, Huajing [1 ]
Mi, Lan [2 ]
Li, Bo [1 ]
Shi, Anhui [1 ]
Yu, Rong [1 ]
Li, Dongming [1 ]
Dong, Xin [1 ]
Yang, Dan [1 ]
Yu, Huiming [1 ]
Wang, Weihu [1 ]
机构
[1] Peking Univ Canc Hosp & Inst, Dept Radiat Oncol, Minist Educ Beijing, Key Lab Carcinogenesis & Translat Res, Beijing, Peoples R China
[2] Peking Univ Canc Hosp & Inst, Dept Lymphoma, Minist Educ Beijing, Key Lab Carcinogenesis & Translat Res, Beijing, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2021年 / 10卷
基金
中国国家自然科学基金;
关键词
non-small cell lung cancer; chemoradiotherapy; cytokines; IL-8; intercellular adhesion molecule 1 (ICAM-1); biomarkers; SURVIVAL; RADIOTHERAPY;
D O I
10.3389/fonc.2020.625911
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose To identify cytokines in plasma that may predict objective response and progression-free survival (PFS) in patients with locally advanced non-small cell lung cancer (NSCLC) treated with chemoradiotherapy. Materials and Methods From April 2016 to May 2017, thirty-one patients with locally advanced inoperable/unresectable NSCLC were included, and treated with concurrent chemoradiotherapy (CCRT). No immune checkpoint inhibitors were administered after CCRT. Plasma from each patient was collected before radiotherapy, and 25 cytokines in the plasma were measured by Luminex or U-PLEX assays. Logistic regression and COX regression were performed to identify the predictive factors for objective response and PFS, respectively. Kaplan-Meier survival analysis was used to compare the PFS between the groups. Results High levels of IL-13 and TNF-alpha, and low levels of ICAM-1, IFN-gamma, and soluble PD-L1 (sPD-L1) were significantly associated with objective response (P <0.05). High levels of IL-8, CCL5, and CXCL3 also showed a trend toward association with objective response (P <0.1). The combination of cytokines (IL-8 and ICAM-1, or TNF-alpha and sPD-L1) improved predictive accuracy. Univariate analysis identified IL-8 and ICAM-1 as potential markers to predict PFS. Multivariate analysis suggested that high level of IL-8 (P =0.010) and low level of ICAM-1 (P =0.011) correlated significantly with a longer PFS. Conclusion IL-8 and ICAM-1 in plasma have the potential to predict objective response and PFS in patients with locally advanced NSCLC underwent chemoradiotherapy.
引用
收藏
页数:8
相关论文
共 50 条
[41]   Efficacy and safety of recombinant human endostatin combined with radiotherapy or chemoradiotherapy in patients with locally advanced non-small cell lung cancer: a pooled analysis [J].
Shu-Ling Zhang ;
Cheng-Bo Han ;
Li Sun ;
Le-Tian Huang ;
Jie-Tao Ma .
Radiation Oncology, 15
[42]   Efficacy and safety of recombinant human endostatin combined with radiotherapy or chemoradiotherapy in patients with locally advanced non-small cell lung cancer: a pooled analysis [J].
Zhang, Shu-Ling ;
Han, Cheng-Bo ;
Sun, Li ;
Huang, Le-Tian ;
Ma, Jie-Tao .
RADIATION ONCOLOGY, 2020, 15 (01)
[43]   The effect of consolidation chemotherapy after concurrent chemoradiotherapy on the survival of patients with locally advanced non-small cell lung cancer: a meta-analysis [J].
Wang, Xinshuai ;
Ding, Xuezhen ;
Kong, Dejiu ;
Zhang, Li ;
Guo, Yibo ;
Ren, Jing ;
Hu, Xiaochen ;
Yang, Junqiang ;
Gao, Shegan .
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 2017, 22 (02) :229-236
[44]   Prediction of response by FDG PET early during concurrent chemoradiotherapy for locally advanced non-small cell lung cancer [J].
Kim, Suzy ;
Oh, So Won ;
Kim, Jin Soo ;
Kim, Ki Hwan ;
Kim, Yu Kyeong .
RADIATION ONCOLOGY JOURNAL, 2014, 32 (04) :231-237
[45]   Declining hemoglobin during chemoradiotherapy for locally advanced non-small cell lung cancer is significant [J].
MacRae, R ;
Shyr, Y ;
Johnson, D ;
Choy, H .
RADIOTHERAPY AND ONCOLOGY, 2002, 64 (01) :37-40
[46]   Survival data in elderly patients with locally advanced non-small cell lung cancer [J].
Domingues, Pedro Masson ;
Zylberberg, Ricardo ;
de Castro, Thalita da Matta ;
Baldotto, Clarissa Serodio ;
de Lima Araujo, Luiz Henrique .
MEDICAL ONCOLOGY, 2013, 30 (01)
[47]   Trends in Cardiac Mortality in Patients With Locally Advanced Non-Small Cell Lung Cancer [J].
Haque, Waqar ;
Verma, Vivek ;
Fakhreddine, Mohamad ;
Butler, E. Brian ;
Teh, Bin S. ;
Simone, Charles B., II .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2018, 100 (02) :470-477
[48]   Survival data in elderly patients with locally advanced non-small cell lung cancer [J].
Pedro Masson Domingues ;
Ricardo Zylberberg ;
Thalita da Matta de Castro ;
Clarissa Seródio Baldotto ;
Luiz Henrique de Lima Araujo .
Medical Oncology, 2013, 30
[49]   Current status and progress of concurrent chemoradiotherapy in patients with locally advanced non-small cell lung cancer prior to the approval of durvalumab [J].
Fukui, Tomoya ;
Hosotani, Shinji ;
Soda, Itaru ;
Ozawa, Takahiro ;
Kusuhara, Seiichiro ;
Kakegawa, Mikiko I. ;
Kasajima, Masashi ;
Hiyoshi, Yasuhiro ;
Igawa, Satoshi ;
Yokoba, Masanori ;
Mitsufuji, Hisashi ;
Kubota, Masaru ;
Katagiri, Masato ;
Sasaki, Jiichiro ;
Ishiyama, Hiromichi ;
Naoki, Katsuhiko .
THORACIC CANCER, 2020, 11 (04) :1005-1014
[50]   Effects of chemoradiotherapy on acute-phase protein levels in glioblastoma multiforme and locally advanced non-small cell lung cancer [J].
Deniz, Cigdem Damla ;
Gurbilek, Mehmet ;
Koc, Mehmet .
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, 2018, 43 (02) :159-166