Rh(III)-catalyzed direct cross-dehydrogenative coupling of aromatic nitriles with heteroarenes: Rapid access to biheteroaryl-2-carbonitriles

被引：21

作者：

Xu, Huibei ^{[1
]}

Zhu, Yanying ^{[1
]}

Chai, Xinyue ^{[1
]}

Yang, Jiahui ^{[1
]}

Dong, Lin ^{[1
]}

机构：

[1] Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst Educ M, Chengdu 610041, Peoples R China

来源：

GREEN SYNTHESIS AND CATALYSIS | 2020年 / 1卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Rh(III)-catalysis; Cross-dehydrogenative coupling; C-H activation; Heteroarylation; Biphenyl-2-carbonitriles; H BOND ACTIVATION; CATALYZED C-H; ANNULATION CASCADE; DIRECT CYANATION; CYANO; INDOLES; RHODIUM; ARENES; FUNCTIONALIZATION; ARYLNITRILES;

D O I：

10.1016/j.gresc.2020.09.001

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Transition-metal-catalyzed direct C-H/C-H cross-coupling reactions as efficient and atom-economical approaches have been widely used to build up complex heterocyclic compounds. However, the strategy for preparation of biphenyl-2-carbonitriles has not been well established. Herein, we described the first cyanogen directed Rh(III)catalyzed CDC reaction of aromatic nitriles with heteroarenes. Various biphenyl-2-carbonitrilederivatives were obtained with broad functional group compatibility.

引用

页码：167 / 170

页数：4

共 67 条

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