Rh(III)-catalyzed direct cross-dehydrogenative coupling of aromatic nitriles with heteroarenes: Rapid access to biheteroaryl-2-carbonitriles

被引：21
作者：
Xu, Huibei [1 ]
Zhu, Yanying [1 ]
Chai, Xinyue [1 ]
Yang, Jiahui [1 ]
Dong, Lin [1 ]
机构：
[1] Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst Educ M, Chengdu 610041, Peoples R China
来源：
GREEN SYNTHESIS AND CATALYSIS | 2020年 / 1卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Rh(III)-catalysis; Cross-dehydrogenative coupling; C-H activation; Heteroarylation; Biphenyl-2-carbonitriles; H BOND ACTIVATION; CATALYZED C-H; ANNULATION CASCADE; DIRECT CYANATION; CYANO; INDOLES; RHODIUM; ARENES; FUNCTIONALIZATION; ARYLNITRILES;
D O I：
10.1016/j.gresc.2020.09.001
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Transition-metal-catalyzed direct C-H/C-H cross-coupling reactions as efficient and atom-economical approaches have been widely used to build up complex heterocyclic compounds. However, the strategy for preparation of biphenyl-2-carbonitriles has not been well established. Herein, we described the first cyanogen directed Rh(III)catalyzed CDC reaction of aromatic nitriles with heteroarenes. Various biphenyl-2-carbonitrilederivatives were obtained with broad functional group compatibility.
引用
收藏
页码：167 / 170
页数：4
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