Immunity against Helicobacter pylori:: Significance of interleukin-4 receptor α chain status and gender of infected mice

被引：52
作者：
Aebischer, T
Laforsch, S
Hurwitz, R
Brombacher, F
Meyer, TF
机构：
[1] Max Planck Inst Infect Biol, Dept Mol Biol, D-10117 Berlin, Germany
[2] Univ Cape Town, Groote Schuur Hosp, Fac Hlth Sci, Infect Dis Unit, ZA-7925 Cape Town, South Africa
来源：
INFECTION AND IMMUNITY | 2001年 / 69卷 / 01期
关键词：
D O I：
10.1128/IAI.69.1.556-558.2001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Vaccination of interleukin-4 (IL-4) receptor alpha (IL-4R alpha) chain-deficient BALB/c mice with Helicobacter pylori urease and cholera toxin or with urease-expressing, live attenuated Salmonella enterica serovar Typhimurium cells revealed that protection against H. pylori infection is independent of IL-4- or IL-13-mediated signals. A comparison of male and female mice suggests a sexual dimorphism in the extent of bacterial colonization that is particularly evident in the absence of the IL-4R alpha chain.
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页码：556 / 558
页数：3
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