Comparative study of chronic kidney disease in dogs and cats: Induction of myofibroblasts

被引：36
作者：
Yabuki, A. [1 ]
Mitani, S. [1 ]
Fujiki, M. [2 ]
Misumi, K. [2 ]
Endo, Y. [3 ]
Miyoshi, N. [4 ]
Yamato, O. [1 ]
机构：
[1] Kagoshima Univ, Dept Vet Med, Lab Vet Clin Pathol, Kagoshima 890, Japan
[2] Kagoshima Univ, Dept Vet Med, Lab Vet Surg, Kagoshima 890, Japan
[3] Kagoshima Univ, Dept Vet Med, Lab Vet Internal Med, Kagoshima 890, Japan
[4] Kagoshima Univ, Dept Vet Med, Lab Vet Pathol, Kagoshima 890, Japan
来源：
RESEARCH IN VETERINARY SCIENCE | 2010年 / 88卷 / 02期
关键词：
Cats; Chronic kidney disease; Dogs; Myofibroblasts; CHRONIC RENAL-DISEASE; MESENCHYMAL TRANSITION; INTERSTITIAL MYOFIBROBLASTS; GLOMERULONEPHRITIS; FIBROSIS; CANINE; CELLS; NEPHROPATHY; EXPRESSION; MECHANISM;
D O I：
10.1016/j.rvsc.2009.09.003
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
We investigated the kidneys of dogs and cats to clarify whether renal myofibroblasts induction is associated with the severity of chronic kidney disease (CKD). Immunohistochemical expression of my3ofibroblast markers, alpha-smooth muscle actin (SMA) and vimentin, were evaluated quantitatively. The degrees of glomerulosclerosis, glomerular hypertrophy, interstitial cell infiltration, and interstitial fibrosis were also evaluated quantitatively. The plasma creatinine (pCre) concentrations correlated with glomerulosclerosis, cell infiltration, and fibrosis in dogs, and only with fibrosis in cats. The alpha-SMA expression correlated with pCre, glomerulosclerosis, cell infiltration, and fibrosis in dogs, and with pCre and fibrosis in cats. Tubular vimentin expression correlated with fibrosis in cats, but not in dogs. Interstitial vimentin expression correlated with pCre, glomerulosclerosis, cell infiltration, and fibrosis in dogs, but only with pCre in cats. In conclusion, it was suggested that the severity of CKD in dogs and cats was mediated by different pathways associated with myofibroblasts expression. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：294 / 299
页数：6
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