The synthesis of gracillin and dioscin: two typical representatives of spirostanol glycosides

被引：36

作者：

Zou, CC

Hou, SJ

Shi, Y

Lei, PS ^{[1
]}

Liang, XT

机构：

[1] Peking Union Med Coll, Inst Mat Med, Beijing 100050, Peoples R China

[2] Chinese Acad Med Sci, Beijing 100050, Peoples R China

来源：

CARBOHYDRATE RESEARCH | 2003年 / 338卷 / 08期

关键词：

spirostanol glycosides; glycosylation; gracillin; dioscin; guanidine;

D O I：

10.1016/S0008-6215(03)00004-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two representative spirostanol saponins that have the typical structure for the sugar moiety, diosgenyl alpha-L-rhamnopyranosyl-(1 --> 2)-[beta-D-glucopyranosyl-(1 --> 3)]-beta-D-glucopyranoside (gracillin) and diosgenyl alpha-L-rhamnopyranosyl-(1 --> 2)-[alpha-L-rhamnopyranosyl-(1 --> 4)]-beta-D-glucopyranoside (dioscin), were easily synthesized by a general approach. A procedure using guanidine for the selective deblocking of acetyl while retaining benzoyl protecting groups is described. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：721 / 727

页数：7

共 21 条

[1] GLYCOSIDES .4. 3,4,6-TRI-0-ACETYL-2-0-BENZYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE [J].