Overview of the oncogenic signaling pathways in colorectal cancer: Mechanistic insights

被引：97

作者：

Farooqi, Ammad Ahmad ^{[1
]}

de la Roche, Marc ^{[2
]}

Djamgoz, Mustafa B. A. ^{[3
,4
]}

Siddik, Zahid H. ^{[5
]}

机构：

[1] IBGE, Islamabad, Pakistan

[2] Univ Cambridge, Dept Biochem, 80 Tennis Court Rd, Cambridge CB2 1GA, England

[3] Imperial Coll London, Dept Life Sci, Neurosci Solut Canc Res Grp, South Kensington Campus, London SW7 2AZ, England

[4] Cyprus Int Univ, Biotechnol Res Ctr, Mersin 10, Haspolat, North Cyprus, Turkey

[5] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2019年 / 58卷

关键词：

DEATH RECEPTOR 5; SODIUM-CHANNEL EXPRESSION; TRAIL-INDUCED APOPTOSIS; POLYPOSIS-COLI PROTEIN; TUMOR-SUPPRESSOR; BETA-CATENIN; IN-VITRO; CHROMOSOMAL INSTABILITY; UP-REGULATION; DOWN-REGULATION;

D O I：

10.1016/j.semcancer.2019.01.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer is a multifaceted disease which is therapeutically challenging. Based on insights gleaned from almost a quarter century of research, it is obvious that deregulation of spatio-temporally controlled signaling pathways play instrumental role in development and progression of colorectal cancer. High-throughput technologies have helped to develop a sharper and broader understanding of the wide ranging signal transduction cascades which also contribute to development of drug resistance, loss of apoptosis and, ultimately, of metastasis. In this review, we have set the spotlight on role of JAK/STAT, TGF/SMAD, Notch, WNT/beta-Catenin, SHH/GLI and p53 pathways in the development and progression of colorectal cancer. We have also highlighted recent reports on TRAIL-mediated pathways and molecularly distinct voltage-gated sodium channels in colorectal cancer.

引用

页码：65 / 79

页数：15

共 173 条

[21] Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types [J].

Chartier, Cecile ;

Raval, Janak ;

Axelrod, Fumiko ;

Bond, Chris ;

Cain, Jennifer ;

Dee-Hoskins, Cristina ;

Ma, Shirley ;

Fischer, Marcus M. ;

Shah, Jalpa ;

Wei, Jie ;

Ji, May ;

Lam, Andrew ;

Stroud, Michelle ;

Yen, Wan-Ching ;

Yeung, Pete ;

Cancilla, Belinda ;

O'Young, Gilbert ;

Wang, Min ;

Kapoun, Ann M. ;

Lewicki, John ;

Hoey, Timothy ;

Gurney, Austin .

CANCER RESEARCH, 2016, 76 (03) :713-723

[22] Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer [J].

Chen, Baozhi ;

Dodge, Michael E. ;

Tang, Wei ;

Lu, Jianming ;

Ma, Zhiqiang ;

Fan, Chih-Wei ;

Wei, Shuguang ;

Hao, Wayne ;

Kilgore, Jessica ;

Williams, Noelle S. ;

Roth, Michael G. ;

Amatruda, James F. ;

Chen, Chuo ;

Lum, Lawrence .

NATURE CHEMICAL BIOLOGY, 2009, 5 (02) :100-107

[23] miR-598 inhibits metastasis in colorectal cancer by suppressing JAG1/Notch2 pathway stimulating EMT [J].

Chen, Jia ;

Zhange, Haichen ;

Chen, Ying ;

Qiao, Guanglei ;

Jiang, Weihua ;

Ni, Peihua ;

Liu, Xiangfan ;

Ma, Lijun .

EXPERIMENTAL CELL RESEARCH, 2017, 352 (01) :104-112

[24] Gefitinib enhances human colon cancer cells to TRAIL-induced apoptosis of via autophagy- and JNK-mediated death receptors upregulation [J].

Chen, Lei ;

Meng, Yue ;

Guo, Xiaoqing ;

Sheng, Xiaotong ;

Tai, Guihua ;

Zhang, Fenglei ;

Cheng, Hairong ;

Zhou, Yifa .

APOPTOSIS, 2016, 21 (11) :1291-1301

[25] Ginsenoside compound K sensitizes human colon cancer cells to TRAIL-induced apoptosis via autophagy-dependent and -independent DR5 upregulation [J].

Chen, Lei ;

Meng, Yue ;

Sun, Qi ;

Zhang, Zhongyu ;

Guo, Xiaoqing ;

Sheng, Xiaotong ;

Tai, Guihua ;

Cheng, Hairong ;

Zhou, Yifa .

CELL DEATH & DISEASE, 2016, 7 :e2334-e2334

[26] A novel polyclonal antibody specific for the Nav 1.5 voltage-gated Na+ channel 'neonatal' splice form [J].

Chioni, AM ;

Fraser, SP ;

Pani, F ;

Foran, P ;

Wilkin, GP ;

Diss, JKJ ;

Djamgoz, MBA .

JOURNAL OF NEUROSCIENCE METHODS, 2005, 147 (02) :88-98

[27] Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis [J].

Christie, M. ;

Jorissen, R. N. ;

Mouradov, D. ;

Sakthianandeswaren, A. ;

Li, S. ;

Day, F. ;

Tsui, C. ;

Lipton, L. ;

Desai, J. ;

Jones, I. T. ;

McLaughlin, S. ;

Ward, R. L. ;

Hawkins, N. J. ;

Ruszkiewicz, A. R. ;

Moore, J. ;

Burgess, A. W. ;

Busam, D. ;

Zhao, Q. ;

Strausberg, R. L. ;

Simpson, A. J. ;

Tomlinson, I. P. M. ;

Gibbs, P. ;

Sieber, O. M. .

ONCOGENE, 2013, 32 (39) :4675-4682

[28] Wnt/β-catenin signaling in development and disease [J].

Clevers, Hans .

CELL, 2006, 127 (03) :469-480

[29] The Intestinal Crypt, A Prototype Stem Cell Compartment [J].

Clevers, Hans .

CELL, 2013, 154 (02) :274-284

[30] p53 Negatively Regulates Transcription of the Pyruvate Dehydrogenase Kinase Pdk2 [J].

Contractor, Tanupriya ;

Harris, Chris R. .

CANCER RESEARCH, 2012, 72 (02) :560-567

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