Recombinant Mycobacterium bovis BCG as an HIV Vaccine Vector

被引：38
作者：
Chapman, Rosamund [1 ]
Chege, Gerald [1 ]
Shephard, Enid [1 ]
Stutz, Helen [1 ]
Williamson, Anna-Lise [1 ,2 ]
机构：
[1] Univ Cape Town, Inst Infect Dis & Mol Med, Fac Hlth Sci, ZA-7925 Cape Town, South Africa
[2] Groote Schuur Hosp, Natl Hlth Lab Serv, ZA-7925 Cape Town, South Africa
来源：
CURRENT HIV RESEARCH | 2010年 / 8卷 / 04期
关键词：
Recombinant BCG; Mycobacterium bovis BCG; HIV; vaccine vector; HUMAN-IMMUNODEFICIENCY-VIRUS; BACILLE CALMETTE-GUERIN; CELLULAR IMMUNE-RESPONSES; CD8(+) T-CELLS; SURFACE PROTEIN-A; COLI BETA-GALACTOSIDASE; EXPRESSING SIV GAG; CLASS-I GENES; MHC CLASS-I; RHESUS MACAQUES;
D O I：
10.2174/157016210791208686
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
HIV-1 has resulted in a devastating AIDS pandemic. An effective HIV/AIDS vaccine that can be used to either, prevent HIV infection, control infection or prevent progression of the disease to AIDS is needed. In this review we discuss the use of Mycobacterium bovis BCG, the tuberculosis vaccine, as a vaccine vector for an HIV vaccine. Numerous features make BCG an attractive vehicle to deliver HIV antigens. It has a good safety profile, elicits long-lasting cellular immune responses and in addition manufacturing costs are affordable, a necessary consideration for developing countries. In this review we discuss the numerous factors that influence generation of a genetically stable recombinant BCG vaccine for HIV.
引用
收藏
页码：282 / 298
页数：17
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