Identification of novel retinal target genes of thyroid hormone in the human WERI cells by expression microarray analysis

被引：26

作者：

Liu, Yan

Fu, Li

Chen, Ding-Geng

Deeb, Samir S.

机构：

[1] Univ Washington, Dept Med & Genome Sci, Div Med Genet, Seattle, WA 98195 USA

[2] S Dakota State Univ, Dept Math & Stat, Brookings, SD 57007 USA

[3] Univ S Dakota, Sanford Sch Med, Dept Surg, Sioux Falls, SD 57105 USA

来源：

VISION RESEARCH | 2007年 / 47卷 / 17期

关键词：

thyroid hormone; target gene; microarray; retina; photoreceptor;

D O I：

10.1016/j.visres.2007.04.023

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Using the human WERI-Rb1 cell line as a model system, we performed a genome-wide search for retinal target genes of thyroid hormone (TH) via expression microarray analysis followed by quantitative real-time RT-PCR verification. We identified 12 novel retinal targets of TH, including 10 up-regulated genes (OPN1MW, OPNiLW, TIMP3, RPILI, GNGT2, CRX, ARR3, GCAP1, IMPDH1, and PDE6C) and 2 down-regulated genes (GNGT1 and GNB3). In addition, we found a number of novel TH-targets that are not currently known to be retinal genes. This is the first report of human retinal targets regulated by thyroid hormone. Published by Elsevier Ltd.

引用

页码：2314 / 2326

页数：13

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