Expression of neurotrophic factors in injured spinal cord after transplantation of human-umbilical cord blood stem cells in rats

被引：30
作者：
Chung, Hyo-jin [1 ]
Chung, Wook-hun [1 ]
Lee, Jae-Hoon [4 ]
Chung, Dai-Jung [1 ]
Yang, Wo-Jong [1 ]
Lee, A-Jin [1 ]
Choi, Chi-Bong [1 ]
Chang, Hwa-Seok [1 ]
Kim, Dae-Hyun [1 ]
Suh, Hyun Jung [1 ]
Lee, Dong-Hun [3 ]
Hwang, Soo-Han [5 ]
Do, Sun Hee [2 ]
Kim, Hwi-Yool [1 ]
机构：
[1] Konkuk Univ, Coll Vet Med, Dept Vet Surg, Seoul 05029, South Korea
[2] Konkuk Univ, Coll Vet Med, Dept Vet Clin Pathol, Seoul 05029, South Korea
[3] Konkuk Univ, Coll Vet Med, Avian Dis Lab, Seoul 05029, South Korea
[4] Gyeongsang Natl Univ, Coll Vet Med, Dept Vet Surg, Jinju 52828, South Korea
[5] Seoul Cord Blood Bank, Histostem Co, Seoul 05372, South Korea
来源：
JOURNAL OF VETERINARY SCIENCE | 2016年 / 17卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
brain-derived neurotrophic factor; nerve growth factor; neurotrophic factor; neurotrophin-3; spinal cord injury; MARROW STROMAL CELLS; FUNCTIONAL RECOVERY; BRAIN; PATHOPHYSIOLOGY; REMYELINATE; MODEL; BDNF;
D O I：
10.4142/jvs.2016.17.1.97
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
We induced percutaneous spinal cord injuries (SCI) using a balloon catheter in 45 rats and transplanted human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) at the injury site. Locomotor function was significantly improved in hUCB-MSCs transplanted groups. Quantitative ELISA of extract from entire injured spinal cord showed increased expression of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and neurotrophin-3 (NT-3). Our results show that treatment of SCI with hUCB-MSCs can improve locomotor functions, and suggest that increased levels of BDNF, NGF and NT-3 in the injured spinal cord were the main therapeutic effect.
引用
收藏
页码：97 / 102
页数：6
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