Biological Effects of Chitosan-Based Dressing on Hemostasis Mechanism

被引：56

作者：

Wang, Yi-Wen ^{[1
]}

Liu, Chuan-Chieh ^{[2
,3
]}

Cherng, Juin-Hong ^{[1
,4
]}

Lin, Chien-Seng ^{[5
]}

Chang, Shu-Jen ^{[6
]}

Hong, Zhi-Jie ^{[7
]}

Liu, Cheng-Che ^{[8
]}

Chiu, Yaw-Kwan ^{[9
,10
]}

Hsu, Sheng-Der ^{[7
]}

Chang, Hung ^{[11
]}

机构：

[1] Natl Def Med Ctr, Dept & Grad Inst Biol & Anat, Taipei 100, Taiwan

[2] Fu Jen Catholic Univ, Sch Med, New Taipei 100, Taiwan

[3] Cardinal Tien Hosp, Dept Cardiol, Taipei 100, Taiwan

[4] Natl Taipei Univ Nursing & Hlth Sci, Dept Gerontol Hlth Care, Taipei 100, Taiwan

[5] Cheng Hsin Rehabil Med Ctr, Dept Emergency & Crit Care Med, Taipei 100, Taiwan

[6] Triserv Gen Hosp, Natl Def Med Ctr, Dept Internal Med, Div Rheumatol Immunol Allergy, Taipei 100, Taiwan

[7] Triserv Gen Hosp, Natl Def Med Ctr, Dept Surg, Div Traumatol, Taipei 100, Taiwan

[8] Natl Def Med Ctr, Grad Inst Physiol, Dept Physiol & Biophys, Taipei 100, Taiwan

[9] Triserv Gen Hosp, Natl Def Med Ctr, Songshan Branch, Dept Pediat,Sch Med, Taipei 100, Taiwan

[10] Natl Def Med Ctr, Grad Inst Med Sci, Taipei 100, Taiwan

[11] Triserv Gen Hosp, Natl Def Med Ctr, Dept Surg, Div Thorac Surg, Taipei 100, Taiwan

来源：

POLYMERS | 2019年 / 11卷 / 11期

关键词：

antithrombin; chitosan dressing; coagulation factor; hemorrhage; hemostasis; BLOOD-COAGULATION; ANTIBACTERIAL ACTIVITY; HEPARIN; DEACETYLATION; POLYMER; CHARGE; MODE;

D O I：

10.3390/polym11111906

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

There have been numerous recent advances in wound care management. Nevertheless, the assessment of hemostatic dressing is essential to enable surgeons and other physicians and healthcare professionals to make the correct decisions regarding the disposition of severe hemorrhage. Here, we investigated the relative efficacies of chitosan-based and conventional gauze dressings in a rat model of femoral artery hemorrhage and in patients with surgical wounds. Dressing effectiveness was evaluated based on hemostatic profiles, biocompatibility, antimicrobial activity, and blood factor responses in coagulation. Relative to standard gauze dressing, the chitosan fiber (CF) dressing treatment significantly shortened the time to hemostasis in injured rats. Moreover, the CF dressing significantly prolonged partial thromboplastin time, enhanced blood absorption, and reduced antithrombin production without altering the prothrombin ratio. Unlike regular gauze bandages, the CF dressing demonstrated remarkable antibacterial activity. The results of this study indicate the effectiveness of chitosan as a hemostatic dressing and elucidate its underlying mechanism. It is possible that chitosan surgical dressings could serve as first-line intervention in hospital emergency care for uncontrolled hemorrhage.

引用

页数：14

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