The Kennedy Pathway-De Novo Synthesis of Phosphatidylethanolamine and Phosphatidylcholine

被引：661

作者：

Gibellini, Federica ^{[1
]}

Smith, Terry K. ^{[1
]}

机构：

[1] Univ St Andrews, Ctr Biomol Sci, St Andrews KY16 9ST, Fife, Scotland

来源：

IUBMB LIFE | 2010年 / 62卷 / 06期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

Kennedy pathway; ethanolamine; choline; CDP-ethanolamine; CDP-choline; CTP-PHOSPHOETHANOLAMINE CYTIDYLYLTRANSFERASE; EUKARYOTIC PHOSPHOLIPID BIOSYNTHESIS; CDP-ETHANOLAMINE PATHWAY; SACCHAROMYCES-CEREVISIAE; CHOLINE KINASE; RAT-LIVER; TRYPANOSOMA-BRUCEI; PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE; SPHINGOLIPID METABOLISM; MOLECULAR DISSECTION;

D O I：

10.1002/iub.337

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The glycerophospholipids phosphatidylcholine (PC) and phosphatidylethanolamine (PE) account for greater than 50% of the total phospholipid species in eukaryotic membranes and thus play major roles in the structure and function of those membranes. In most eukaryotic cells, PC and PE are synthesized by an aminoalcoholphosphotransferase reaction, which uses sn-1,2-diradylglycerol and either CDP-choline or CDP-ethanolamine, respectively. This is the last step in a biosynthetic pathway known as the Kennedy pathway, so named after Eugene Kennedy who elucidated it over 50 years ago. This review will cover various aspects of the Kennedy pathway including: each of the biosynthetic steps, the functions and roles of the phospholipid products PC and PE, and how the Kennedy pathway has the potential of being a chemotherapeutic target against cancer and various infectious diseases. (C) 2010 IUBMB IUBMB Life, 62(6): 414-428, 2010

引用

页码：414 / 428

页数：15

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