Efficient Bimetallic Catalysis of Nitrile Hydration to Amides with a Simple Pd(OAc)2/Lewis Acid Catalyst at Ambient Temperature

被引：47

作者：

Zhang, Sicheng ^{[1
]}

Xu, Haosheng ^{[1
]}

Lou, Chenlin ^{[1
]}

Senan, Ahmed M. ^{[1
]}

Chen, Zhuqi ^{[1
]}

Yin, Guochuan ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Key Lab Mat Chem Energy Convers & Storage, Minist Educ, Hubei Key Lab Mat Chem & Serv Failure, Wuhan 430074, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 2017卷 / 14期

基金：

中国国家自然科学基金;

关键词：

Nitrile hydration; Bimetallic catalysts; Lewis acids; Palladium; Amides; Homogeneous catalysis; PALLADIUM(II) ACETATE; SELECTIVE HYDRATION; PHYSICOCHEMICAL PROPERTIES; DIOXYGEN ACTIVATION; MANGANESE COMPLEXES; BRIDGED COMPLEXES; AQUEOUS-MEDIUM; METAL-IONS; HYDROLYSIS; MILD;

D O I：

10.1002/ejoc.201601495

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Transition-metal-catalyzed nitrile hydration is an atom-economic method for the synthesis of various amides. This work demonstrates for the first time that the addition of non-redox metal ions like Sc3+ dramatically accelerate the hydration of various nitriles to amides at ambient temperature with the simple Pd(OAc)(2) salt as catalyst, whereas the reactions with Pd(OAc)(2) alone were very sluggish. The formation of a heterobimetallic Pd-II/Sc-III species has been proposed as the key species for the hydration that demonstrates a bimetallic synergistic effect in this process.

引用

收藏

页码：1870 / 1875

页数：6

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