Biology of recently discovered cytokines: Discerning the pro- and anti-inflammatory properties of interleukin-27

被引：49
|
作者：
Villarino, AV [1 ]
Hunter, CA [1 ]
机构：
[1] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA
来源：
ARTHRITIS RESEARCH & THERAPY | 2004年 / 6卷 / 05期
关键词：
IL-27; WSX-1; Th1; Th2; infection;
D O I：
10.1186/ar1227
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
IL-27 is a recently identified heterodimeric cytokine produced in response to microbial and host derived inflammatory cues. Initial studies indicated that IL-27 promotes the generation of Th1 responses required for resistance to intracellular infection and unveiled the molecular mechanisms mediating this effect. However, subsequent work uncovered a role for IL-27 in the suppression of Th1 and Th2 responses. Thus, by discussing its pleotropic functions in the context of infection-induced immunity and by drawing parallels to fellow IL-6/IL-12 family cytokines, this review will attempt to reconcile the pro- and anti-inflammatory effects of IL-27.
引用
收藏
页码：225 / 233
页数：9
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