First report on the nationwide prevalence of paediatric type 1 diabetes in Serbia and temporal trends of diabetes ketoacidosis at diagnosis-a multicentre study

被引：1

作者：

Stankovic, Sandra ^{[1
]}

Vukovic, Rade ^{[2
]}

Vorgucin, Ivana ^{[3
]}

Zdravkovic, Vera ^{[4
]}

Folic, Nevena ^{[5
]}

Zivic, Sasa ^{[6
]}

Ignjatovic, Aleksandra ^{[7
]}

Rancic, Natasa ^{[8
]}

Milenkovic, Tatjana ^{[2
]}

Todorovic, Sladana ^{[2
]}

Mitrovic, Katarina ^{[2
]}

Jesic, Maja ^{[4
]}

Sajic, Silvija ^{[4
]}

Bojic, Vlada ^{[4
]}

Katanic, Dragan ^{[3
]}

Dautovic, Slavica ^{[9
]}

Cvetkovic, Vesna ^{[10
]}

Saranac, Ljiljana ^{[6
]}

Markovic, Slavica ^{[5
]}

Tucakovic, Tatjana ^{[11
]}

Lesovic, Snezana ^{[12
]}

Ljubojevic, Mirjana ^{[12
]}

Ilic, Tatjana ^{[13
]}

Vrebalov, Mirjana ^{[14
]}

Mikic, Marina ^{[15
]}

Jelenkovic, Bratimirka ^{[16
]}

Petrovic, Rada ^{[17
]}

Saric, Snezana ^{[18
]}

Simic, Danijela ^{[19
]}

Cukanovic, Milanko ^{[20
]}

Stankovic, Miodrag ^{[21
]}

机构：

[1] Children Clin, Med Fac, Pediat Endocrinol, Nish, Serbia

[2] Mother & Child Hlth Care Inst Serbia Dr Vukan Cup, Dept Endocrinol, Belgrade, Serbia

[3] Med Fac, Inst Children & Youth Hlth Care Vojvodina, Endocrinol, Novi Sad, Serbia

[4] Univ Children Hosp, Med Fac, Dept Endocrinol, Belgrade, Serbia

[5] Univ Kragujevac, Med Fac, Clin Ctr Kragujevac, Paediat Clin, Kragujevac, Serbia

[6] Univ Nis, Fac Med Nis, Dept Endocrinol, Nish, Serbia

[7] Univ Nis, Fac Med Nis, Dept Med Stat, Nish, Serbia

[8] Univ Nis, Fac Med, Epidemiol, Nish, Serbia

[9] Inst Children & Youth Hlth Care Vojvodina, Endocrinol, Novi Sad, Serbia

[10] Pediat Clin, Dept Endocrinol, Nish, Serbia

[11] Gen Hosp Kraljevo, Kraljevo, Serbia

[12] Gen Hosp Uzice, Uzice, Serbia

[13] Gen Hosp Subotica, Subotica, Serbia

[14] Gen Hosp Zrenjanin, Zrenjanin, Serbia

[15] Gen Hosp Cuprija, Cuprija, Serbia

[16] Gen Hosp Zajeca, Zajeca, Serbia

[17] Gen Hosp Cacak, Cacak, Serbia

[18] Gen Hosp Lozn, Loznica, Serbia

[19] Gen Hosp Sombor, Sombor, Serbia

[20] Special Hosp Bukovicka Banja, Bukovicka Banja, Serbia

[21] Univ Nis, Fac Med, Nish, Serbia

来源：

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM | 2021年 / 34卷 / 02期

关键词：

CHILDREN;

D O I：

10.1515/jpem-2020-0405

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We aimed to collect data on all paediatric patients who were diagnosed with type 1 diabetes mellitus (T1DM) between the years 2000 and 2019 in Serbia and estimate for the first time its prevalence. Also, the trends of diabetes ketoacidosis (DKA) occurrence at the time of diagnosis are monitored. We collected and retrospectively analysed the data of patients <19 years with newly diagnosed T1DM. T1DM was diagnosed in 3134 patients (53.2% male). Total number of youth <19 years with T1DM was 1735 with prevalence of 135.25/100000 at the end of study period. T1DM was diagnosed most frequently between the ages of 5 and 11 years (42.1%). At the time of diagnosis, 35.7% presented in DKA. The incidence and severity of DKA were more significant at the youngest age (p<0.001). There were significant annual percentage increase (2.2%) in the number of new cases of DKA (p=0.007). Conclusion: This first report of nationwide prevalence of T1DM in youth shows that Serbia is among countries with high prevalence of T1DM in youth. System changes are needed in order to provide better quality of health care to these patients.

引用

页码：225 / 229

页数：5

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