Shuttling between species for pathways of lifespan regulation: a central role for the vitellogenin gene family?

被引:30
作者
Brandt, BW
Zwaan, BJ
Beekman, M
Westendorp, RGJ
Slagboom, PE
机构
[1] Leiden Univ, Med Ctr, Dept Med Stat & Bioinformat, Sect Mol Epidemiol, NL-2300 RA Leiden, Netherlands
[2] Leiden Univ, Med Ctr, Dept Gen Internal Med, Sect Gerontol & Geriatr, Leiden, Netherlands
关键词
D O I
10.1002/bies.20161
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Studies to find genes that affect maximum lifespan aim at identifying important determinants of ageing that may be universal across species. Model organisms show insulin signalling can play an important role in ageing. In view of insulin resistance, such loci can also be important in human ageing and health. The study of long-lived humans and their children points to the relevance of lipoprotein profiles and particle size for longevity. If ageing pathways are conserved, then the genes mediating such pathways may also be conserved. Cross-species sequence comparisons of potential longevity loci may reveal whether the pathways that they represent are central themes in lifespan regulation. Using bioinformatic tools, we performed a sequence comparison of the genes involved in lipid metabolism identified in humans as potential longevity loci. This analysis revealed that lipid storage and transport may be a common theme related to longevity in humans, honeybees and nematodes. Here, the vitellogenin family emerges as a potential key connection between lipid metabolism and the insulin/IGF-1 signalling pathway. (C) 2005 Wiley Periodicals, Inc.
引用
收藏
页码:339 / 346
页数:8
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