Fractional CO2 laser for genitourinary syndrome of menopause in breast cancer survivors: clinical, immunological, and microbiological aspects

被引：53

作者：

Becorpi, Angelamaria ^{[1
]}

Campisciano, Giuseppina ^{[2
]}

Zanotta, Nunzia ^{[2
]}

Tredici, Zelinda ^{[1
]}

Guaschino, Secondo ^{[1
]}

Petraglia, Felice ^{[1
]}

Pieralli, Annalisa ^{[1
]}

Sisti, Giovanni ^{[1
]}

De Seta, Francesco ^{[2
,3
]}

Comar, Manola ^{[2
,3
]}

机构：

[1] Careggi Univ Hosp, Sect Gynecol & Obstet, Dept Woman & Child Hlth, Largo Brambilla 3, I-50144 Florence, Italy

[2] IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Via Istria 65-1, I-34100 Trieste, Italy

[3] Univ Trieste, Dept Med Sci, Piazzale Europa 1, I-34127 Trieste, Italy

来源：

LASERS IN MEDICAL SCIENCE | 2018年 / 33卷 / 05期

关键词：

Fractional CO2 laser; Cytokines/chemokines; Microbiome; Menopause; Breast cancer; VULVO-VAGINAL ATROPHY; TREATMENT MODALITY; LASER THERAPY; WOMEN; ASSOCIATION; EFFICACY; SAFETY; TISSUE; FLORA;

D O I：

10.1007/s10103-018-2471-3

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The composition of vaginal microbiome in menopause and cancer survivor women changes dramatically leading to genitourinary syndrome of menopause (GSM) in up to 70% of patients. Recent reports suggest that laser therapy may be valuable as a not hormonal therapeutic modality. The aim of the present study was to evaluate the effects of fractional CO2 laser treatment on the vaginal secretory pathway of a large panel of immune mediators, usually implicated in tissue remodeling and inflammation, and on microbiome composition in postmenopausal breast cancer survivors. The Ion Torrent PGM platform and the Luminex Bio-Plex platform were used for microbiome and immune factor analysis. The significant reduction of clinical symptoms and the non-significant changes in vaginal microbiome support the efficacy and safety of laser treatment. Moreover, the high remodeling status in vaginal epithelium is demonstrated by the significant changes in inflammatory and modulatory cytokine patterns. Laser therapy can be used for the treatment of GSM symptoms and does not show any adverse effects. However, further studies will be needed to clarify its long-term efficacy and other effects.

引用

页码：1047 / 1054

页数：8

共 33 条

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