Prevalence of Latent Mycobacterium Tuberculosis Infection (LTBI) in Saudi Arabia; Population based survey

被引:20
作者
Balkhy, Hanan H. [1 ,2 ,3 ]
El Beltagy, Kamel [3 ,4 ]
El-Saed, Aiman [3 ,5 ]
Aljasir, Badr [1 ,6 ]
Althaqafi, Abdulhakeem [1 ,3 ]
Alothman, Adel F. [1 ,7 ]
Alshalaan, Mohammad [1 ,8 ]
Al-Jahdali, Hamdan [1 ,7 ]
机构
[1] King Saud Bin Abdulaziz Univ Hlth Sci, Minist Natl Guard Hlth Affairs, Riyadh, Saudi Arabia
[2] Minist Natl Guard Hlth Affairs, King Abdullah Int Med Res Ctr, Riyadh, Saudi Arabia
[3] King Abdul Aziz Med City, Minist Natl Guard Hlth Affairs, Infect Prevent & Control Dept, Riyadh, Saudi Arabia
[4] Tanta Univ, Fac Med, Publ Hlth & Community Med Dept, Tanta, Egypt
[5] Mansoura Univ, Fac Med, Publ Hlth & Community Med Dept, Mansoura, Egypt
[6] King Abdul Aziz Med City, Minist Natl Guard Hlth Affairs, Prevent Med Dept, Riyadh, Saudi Arabia
[7] King Abdul Aziz Med City, Minist Natl Guard Hlth Affairs, Dept Med, Riyadh, Saudi Arabia
[8] King Abdul Aziz Med City, Minist Natl Guard Hlth Affairs, Dept Pediat, Riyadh, Saudi Arabia
关键词
Latent Tuberculosis Infection; Prevalence; QuantiFERON TB Gold test; Tuberculin Skin Test; Saudi Arabia; ANNUAL RISK; SKIN-TEST; TB GOLD; EPIDEMIOLOGY; DIAGNOSIS;
D O I
10.1016/j.ijid.2017.03.024
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background: The annual risk of tuberculosis infection (ARTI) data in Saudi Arabia has not been updated since 1993. Objectives: To estimate the prevalence of latent TB infection (LTBI) and ARTI in a population- based sample in Saudi Arabia using Tuberculin skin test (TST) and QuantiFERON TB Gold in tube (QFT-GIT) test. Methods: A population- based cross sectional study was conducted between July 2010 and March 2013. Participants were randomly selected from the population served by the primary healthcare centers of the Ministry of National Guard Health Affairs in Riyadh, Jeddah, Alhassa and Dammam, Saudi Arabia. Results: A total of 1369 participants were included. The overall prevalence of LTBI was similar using TST and QFT-GIT (9.3% and 9.1% respectively, p = 0.872) but stratified prevalence rates were variable in all sociodemographic groups except marital status. Additionally, the prevalence rates of LTBI using either test alone showed significant differences by several sociodemographic and behavioral characteristics. The overall ARTI was 0.36% using TST and 0.35% using QFT-GIT. Conclusions: We are reporting much lower estimates for the prevalence of LTBI and the ARTI in a population-based sample in Saudi Arabia relative to the data that have been used for more than two decades. (C) 2017 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license
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收藏
页码:11 / 16
页数:6
相关论文
共 22 条
[1]   Comparison of the tuberculin skin test and Quanti-FERON-TB Gold In-Tube (QFT-G) test for the diagnosis of latent tuberculosis infection in dialysis patients [J].
Al Jahdali, Hamdan ;
Ahmed, Anwar E. ;
Balkhy, Hanan H. ;
Baharoon, Salim ;
Al Hejaili, Fayez F. ;
Hajeer, Ali ;
Memish, Ziad ;
Binsalih, Salih ;
Al Sayyari, Abdullah A. .
JOURNAL OF INFECTION AND PUBLIC HEALTH, 2013, 6 (03) :166-172
[2]   The use of Quantiferon-TB gold in-tube test in screening latent tuberculosis among Saudi Arabia dialysis patients [J].
Al Wakeel, Jamal Saleh ;
Makoshi, Ziyad ;
Al Ghonaim, Mohammed ;
Al Harbi, Ali ;
Al Suwaida, Abdulkareem ;
Algahtani, Farjah ;
Al Hedaithy, Mogbil ;
Almogairin, Sultan ;
Abdullah, Sami .
ANNALS OF THORACIC MEDICINE, 2015, 10 (04) :284-288
[3]   Current trends of Mycobacterium tuberculosis molecular epidemiology in Saudi Arabia and associated demographical factors [J].
Al-Hajoj, Sahal ;
Varghese, Bright ;
Al-Habobe, Farah ;
Shoukri, Mohammed M. ;
Mulder, Arnout ;
van Soolingen, Dick .
INFECTION GENETICS AND EVOLUTION, 2013, 16 :362-368
[4]   The utility and interpretation of tuberculin skin tests in the Middle East [J].
Al-Jahdali, H ;
Memish, ZA ;
Menzies, D .
AMERICAN JOURNAL OF INFECTION CONTROL, 2005, 33 (03) :151-156
[5]   NATIONWIDE COMMUNITY SURVEY OF TUBERCULOSIS EPIDEMIOLOGY IN SAUDI-ARABIA [J].
ALKASSIMI, FA ;
ABDULLAH, AK ;
ALHAJJAJ, MS ;
ALORAINEY, IO ;
BAMGBOYE, EA ;
CHOWDHURY, MNH .
TUBERCLE AND LUNG DISEASE, 1993, 74 (04) :254-260
[6]  
ALRAIJHI AA, 2004, TUBERCULOSIS, P45
[7]   Do the tuberculin skin test and the QuantiFERON-TB Gold in-tube test agree in detecting latent tuberculosis among high-risk contacts? A systematic review and meta-analysis [J].
Ayubi, Erfan ;
Doosti-Irani, Amin ;
Mostafavi, Ehsan .
EPIDEMIOLOGY AND HEALTH, 2015, 37
[8]   Comparison of QuantiFERON-TB gold in tube test versus tuberculin skin test for screening of latent tuberculosis infection in Saudi Arabia: A population-based study [J].
Balkhy, Hanan H. ;
El Beltagy, Kamel ;
El-Saed, Aiman ;
Aljasir, Badr ;
Althaqafi, Abdulhakeem ;
Alothman, Adel F. ;
Alshalaan, Mohammad ;
Al-Jahdali, Hamdan .
ANNALS OF THORACIC MEDICINE, 2016, 11 (03) :197-201
[9]  
Bener A, 1993, Indian J Public Health, V37, P105
[10]   THE ANNUAL RISK OF TUBERCULOSIS INFECTION USED AS PREDICTOR OF THE FUTURE INCIDENCE OF SMEAR-POSITIVE CASES [J].
ELKASSIMI, FA .
RESPIRATORY MEDICINE, 1994, 88 (08) :589-592