Comparative effects and metabolism of two microcystins and nodularin in the brine shrimp Artemia salina

被引：93
作者：
Beattie, KA
Ressler, J
Wiegand, C
Krause, E
Codd, GA
Steinberg, CEW
Pflugmacher, S
机构：
[1] AG Detoxicat & Metab, Leibniz Inst Freshwater Ecol & Inland Fisheries, D-12561 Berlin, Germany
[2] Univ Dundee, Sch Life Sci, Div Environm & Appl Biol, Dundee DD1 4HN, Scotland
[3] Inst Mol Pharmacol, D-13125 Berlin, Germany
来源：
AQUATIC TOXICOLOGY | 2003年 / 62卷 / 03期
关键词：
cyanobacterial toxins; microcystin; nodularin; Artemia; glutathione S-transferase;
D O I：
10.1016/S0166-445X(02)00091-7
中图分类号：
Q17 [水生生物学];
学科分类号：
071004 ;
摘要：
The toxicity and metabolism of the cyanobacterial toxins microcystin-LR (MCLR), Dhb-microcystin-HtyR and nodularin were investigated in the cysts, nauplii and adults of the brine shrimp Artemia salina. The presence of the phase 11 detoxication system glutathione S-transferase (sGST) in these stages was shown using different substrates. Exposure of adult A. salina to the toxins led to an elevation of GST activity in vivo. All three toxins were conjugated to glutathione via GST, which has been shown as an initial step of microcystin and nodularin detoxication. (C) 2002 Elsevier Science B.V. All rights reserved.
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页码：219 / 226
页数：8
相关论文
共 35 条
  • [1] BEATTIE KA, 1993, THESIS U DUNDEE
  • [2] BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
  • [3] COMPARATIVE-ASSESSMENT OF THE SPECIFICITY OF THE BRINE SHRIMP AND MICROTOX ASSAYS TO HEPATOTOXIC (MICROCYSTIN-LR-CONTAINING) CYANOBACTERIA
    CAMPBELL, DL
    LAWTON, LA
    BEATTIE, KA
    CODD, GA
    [J]. ENVIRONMENTAL TOXICOLOGY AND WATER QUALITY, 1994, 9 (01): : 71 - 77
  • [4] Cyanobacterial toxins, exposure routes and human health
    Codd, GA
    Bell, SG
    Kaya, K
    Ward, CJ
    Beattie, KA
    Metcalf, JS
    [J]. EUROPEAN JOURNAL OF PHYCOLOGY, 1999, 34 (04) : 405 - 415
  • [5] EFFECTS OF TOXIC CYANOBACTERIA AND PURIFIED TOXINS ON THE SURVIVAL AND FEEDING OF A COPEPOD AND 3 SPECIES OF DAPHNIA
    DEMOTT, WR
    ZHANG, QX
    CARMICHAEL, WW
    [J]. LIMNOLOGY AND OCEANOGRAPHY, 1991, 36 (07) : 1346 - 1357
  • [6] FJELLSTEDT TA, 1973, J BIOL CHEM, V248, P3702
  • [7] Habig W, 1974, J BIOL CHEM, V249, P1730
  • [8] Ketterer B, 1988, GLUTATHIONE CONJUGAT
  • [9] DETECTION OF TOXICITY OF CYANOBACTERIA BY ARTEMIA-SALINA BIOASSAY
    KIVIRANTA, J
    SIVONEN, K
    NIEMELA, SI
    HUOVINEN, K
    [J]. ENVIRONMENTAL TOXICOLOGY AND WATER QUALITY, 1991, 6 (04): : 423 - 436
  • [10] FORMATION, CHARACTERIZATION, AND TOXICITY OF THE GLUTATHIONE AND CYSTEINE CONJUGATES OF TOXIC HEPTAPEPTIDE MICROCYSTINS
    KONDO, F
    IKAI, Y
    OKA, H
    OKUMURA, M
    ISHIKAWA, N
    HARADA, K
    MATSUURA, K
    MURATA, H
    SUZUKI, M
    [J]. CHEMICAL RESEARCH IN TOXICOLOGY, 1992, 5 (05) : 591 - 596
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