Multicompartment micelles based on hierarchical co-assembly of PCL-b-PEG and PCL-b-P4VP diblock copolymers

被引：7

作者：

Liu, Xue ^{[1
]}

Hou, Yu ^{[1
]}

Tang, Xiuping ^{[1
]}

Wu, Qiuhua ^{[1
]}

Wu, Chenglin ^{[2
]}

Yi, Jie ^{[1
]}

Zhang, Guolin ^{[1
]}

机构：

[1] Liaoning Univ, Coll Chem, Liaoning Prov Key Lab Green Synth & Preparat Chem, Shenyang 110036, Peoples R China

[2] Taizhou Univ, Sch Pharmaceut & Chem Engn, Taizhou 317000, Peoples R China

来源：

RSC ADVANCES | 2016年 / 6卷 / 07期

关键词：

COMPLEX MICELLES; BLOCK-COPOLYMERS; POLYMER MICELLES; TERPOLYMERS; DELIVERY; RELEASE; SHELL; SOFT;

D O I：

10.1039/c5ra22299k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Multicompartment micelles are prepared via the hierarchical co-assembly of two diblock copolymers, poly(3-caprolactone)-b-poly(ethylene glycol) (PCL-b-PEG) and poly(3-caprolactone)-b-poly(4vinylpyridine) (PCL-b-P4VP) in aqueous solution. These two polymers first assemble into mixed shell micelles through hydrophobic interaction among PCL chains. PCL chains form the micellar core, while PEG and P4VP chains form the micellar shell. Regulating the pH value above the pKa of P4VP can induce hydrophobic phase-segregated P4VP patches forming on the surface of mixed shell micelles. When hydrophilic PEG chains cannot stabilize theses micelles with hydrophobic patches, they will furthermore assemble as the subunits into MMs with different morphologies. These MMs can be revealed by transmission electron microscopy through P4VP chains positive staining.

引用

页码：5312 / 5319

页数：8

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