Blocking of TRPM2 channels protects from ischemic neurodegeneration in mice by reducing oxidative stress, blood-brain-barrier damage and inflammation

被引:0
|
作者
Melzer, N. [1 ]
Hicking, G. [1 ]
Goeb, E. [2 ]
Bittner, S. [1 ]
Herrmann, A. M. [1 ]
Wiendl, H. [1 ]
Kleinschnitz, C. [2 ]
Meuth, S. G. [1 ]
机构
[1] Univ Munster, Dept Neurol, D-48149 Munster, Germany
[2] Univ Wurzburg, Dept Neurol, Wurzburg, Germany
关键词
D O I
暂无
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
EP3212
引用
收藏
页码:S195 / S195
页数:1
相关论文
共 50 条
  • [41] N-Acetylcysteine Amide (NACA): a Thiol Antioxidant Protects Blood Brain Barrier From Oxidative Stress Induced Damage in Animals Challenged With Gp120, Tat and Metaphetamine
    Banerjee, Atrayee
    Zhang, Xinsheng
    Manda, Kalyan
    Banks, William A.
    Ercal, Nuran
    FREE RADICAL BIOLOGY AND MEDICINE, 2008, 45 : S79 - S79
  • [42] Mogroside-rich extract from Siraitia grosvenorii fruits protects against heat stress-induced intestinal damage by ameliorating oxidative stress and inflammation in mice
    Lu, Renhong
    Hu, Jiahao
    Liu, Xinxin
    Yu, Lijiang
    Hu, Junjie
    Jiang, Huimin
    Liu, Shaoyuan
    Li, Mengqi
    He, Jiakang
    Yang, Xiaogan
    Liang, Xingwei
    FOOD & FUNCTION, 2023, 14 (02) : 1238 - 1247
  • [43] Baicalin protects LPS-induced blood-brain barrier damage and activates Nrf2-mediated antioxidant stress pathway
    Wang, Xin
    Yu, Jia-ying
    Sun, Yan
    Wang, Heng
    Shan, Hu
    Wang, Shubai
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2021, 96
  • [44] Melatonin decreases neurovascular oxidative/nitrosative damage and protects against early increases in the blood-brain barrier permeability after transient focal cerebral ischemia in mice
    Chen, Hung-Yi
    Chen, Tsung-Ying
    Lee, Ming-Yang
    Chen, Shur-Tzu
    Hsu, Yun-Shang
    Kuo, Yen-Liang
    Chang, Guan-Liang
    Wu, Tian-Shung
    Lee, E-Jian
    JOURNAL OF PINEAL RESEARCH, 2006, 41 (02) : 175 - 182
  • [45] Mfsd2a attenuated hypoxic-ischemic brain damage via protection of the blood-brain barrier in mfat-1 transgenic mice
    Li, Xiaoxue
    Zhang, Yumeng
    Chang, Jianghao
    Zhang, Chenglin
    Li, Lin
    Dai, Yifan
    Yang, Haiyuan
    Wang, Ying
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2023, 80 (03)
  • [47] Genistein mitigates oxidative stress and inflammation by regulating Nrf2/HO-1 and NF-κB signaling pathways in hypoxic-ischemic brain damage in neonatal mice
    Li, Yuan
    Zhang, Jin-Jia
    Chen, Ru-Jia
    Chen, Ling
    Chen, Su
    Yang, Xiao-Fei
    Min, Jia-Wei
    ANNALS OF TRANSLATIONAL MEDICINE, 2022, 10 (02)
  • [48] MiR-17-5p protects neonatal mice from hypoxic-ischemic brain damage by targeting Casp2
    Niu, Xiaolin
    Jiao, Zhongmiao
    Wang, Zhiguo
    Jiang, Aiping
    Zhang, Xia
    Zhang, Hui
    Xue, Fei
    NEUROSCIENCE LETTERS, 2022, 772
  • [49] Hydrogen Sulfide Protects Brain from Oxidative Stress in Cerebral Ischemic Reperfusion Injury Model via Nrf-2 Signalling Pathway
    Ryu, Wi-Sun
    Kim, Chi Kyung
    Kim, Beom Joon
    Lee, Seung-Hoon
    Yoon, Byung-Woo
    CEREBROVASCULAR DISEASES, 2012, 34 : 120 - 120
  • [50] 3K3A-Activated Protein C Protects the Blood-Brain Barrier and Neurons From Accelerated Ischemic Injury Caused by Pericyte Deficiency in Mice
    Wang, Yaoming
    Kisler, Kassandra
    Nikolakopoulou, Angeliki Maria
    Fernandez, Jose A.
    Griffin, John H.
    Zlokovic, Berislav
    FRONTIERS IN NEUROSCIENCE, 2022, 16