EVALUATION OF POLYQUATERNIUM-1 EFFECTS ON HUMAN CORNEAL EPITHELIAL CELLS

被引：0
作者：
Wang, Rui [1 ]
Zhao, Yujia [2 ]
Jiao, Yang [3 ]
Li, Xiaohua [1 ]
机构：
[1] Mu Dan Jiang Med Univ, Hong Qi Hosp, Dept Ophthalmol, Mu Dan Jiang City 157011, Peoples R China
[2] Mu Dan Jiang Med Univ, Coll Pharm, Mu Dan Jiang City 157011, Peoples R China
[3] Mu Dan Jiang Med Univ, Hong Qi Hosp, Dept Neurol 1, Mu Dan Jiang City 157011, Peoples R China
来源：
FARMACIA | 2017年 / 65卷 / 04期
关键词：
polyquatemium-1; corneal epithelial cells; cytotoxicity; antibacterial activity; BROTH MICRODILUTION METHOD; SURGICAL SITE INFECTIONS; BENZALKONIUM CHLORIDE; ANTIMICROBIAL RESISTANCE; EYE DROPS; PRESERVATIVES; MECHANISMS; DIAGNOSIS; MODEL; FOCUS;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The aim of this study was to evaluate the antibacterial activity of polyquaternium-1 and its toxicity on human corneal epithelial cells. The antibacterial activity of polyquaternium-1 (PQ-1) samples was measured by nutrient broth dilution method, and the influence of external factors on the stability of PQ-1 was investigated. The cytotoxicity of polyquaternium-1 was evaluated using an in vitro cell model of human corneal epithelium HCEpiC. The PQ-1 samples had a good antibacterial activity, which was not affected by UV irradiation and pH. The antibacterial activity decreased with the increase of temperature and NaCl. In addition, the PQ-1 high concentration had certain toxic effects on HCEpiC, but the cytotoxicity of PQ-1 was low compared with other tested antibacterial agents. Polyquaternium-1 is a good choice as an ophthalmic bacteriostatic agent, being non-irritant and having strong antibacterial activity, low toxicity, and low cytotoxicity on human corneal epithelial cells.
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收藏
页码：584 / 590
页数：7
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