Lipoxins and synthetic lipoxin mimetics: Therapeutic potential in renal diseases

被引：18
作者：
Andrews, Darrell [1 ,2 ]
Godson, Catherine [1 ,2 ]
机构：
[1] Univ Coll Dublin, Diabet Complicat Res Ctr, Conway Inst, Dublin, Ireland
[2] Univ Coll Dublin, Sch Med, Dublin, Ireland
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2021年 / 1866卷 / 08期
基金：
爱尔兰科学基金会;
关键词：
Lipoxins; Resolution of inflammation; Renal inflammation; Fibrosis; AT-01-KG; Cellular plasticity; ASPIRIN-TRIGGERED LIPOXIN; A(4) STABLE ANALOGS; RESOLVING LIPID MEDIATORS; ANTIINFLAMMATORY ACTIONS; 15-EPI-LIPOXIN A(4); B-4; ANALOGS; STEM-CELLS; APOPTOTIC NEUTROPHILS; MACROPHAGE PHENOTYPE; KIDNEY REGENERATION;
D O I：
10.1016/j.bbalip.2021.158940
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Inflammation and its timely resolution are critical to ensuring effective host defence and appropriate tissue repair after injury. Unresolved inflammation typifies many renal pathologies. The key drivers of the inflammatory response are well defined and targeted by conventional anti-inflammatory therapeutics. However, these are associated with undesirable side effects including immune suppression. More recently, there is growing appreciation that specialized lipid mediators [SPMs] including lipoxins promote the resolution of inflammation and endogenous repair mechanisms without compromising host defence. We discuss the pro-resolving bioactions of lipoxins and recent work that aims to harness their therapeutic potential in the context of kidney disease.
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页数：8
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