Regulatory roles of the bacterial nitrogen-related phosphotransferase system

被引：121

作者：

Pflueger-Grau, Katharina ^{[2
]}

Goerke, Boris ^{[1
]}

机构：

[1] Univ Gottingen, Dept Gen Microbiol, Inst Microbiol & Genet, D-37077 Gottingen, Germany

[2] CSIC, CNB, Syst Biol Program, Canto Blanco 28049, Spain

来源：

TRENDS IN MICROBIOLOGY | 2010年 / 18卷 / 05期

关键词：

PUTIDA TOL PLASMID; ENZYME I-NTR; SIGNATURE-TAGGED MUTAGENESIS; CARBON CATABOLITE REPRESSION; TOLUENE DEGRADATION PATHWAY; SIGMA(54) PU PROMOTER; PSEUDOMONAS-PUTIDA; ESCHERICHIA-COLI; PROTEIN IIA(NTR); CAENORHABDITIS-ELEGANS;

D O I：

10.1016/j.tim.2010.02.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In addition to the sugar phosphotransferase system (sugar PTS) dedicated to carbohydrate uptake, many Gram-negative bacteria possess a so-called nitrogen PTS (PTSNtr). Although fulfilling very different functions, both systems can communicate with each other by phosphate exchange. PTSNtr regulates diverse processes implicated in metabolism of nitrogen and carbon, and is essential for virulence in some bacteria. Additionally, it plays a role in potassium homeostasis by regulating the expression and activity of a high- and a low-affinity K+ transporter, respectively. In this article, we review recent advances in the understanding of the regulatory roles of PTSNtr in various organisms.

引用

页码：205 / 214

页数：10

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