Hemophagocytic lymphohistiocytosis presenting with annular erythema multiforme-like eruptions in a patient with angioimmunoblastic T cell lymphoma: A case report

被引:3
|
作者
Zhang, Liping [1 ]
Tong, Chunguang [2 ]
Tan, Yaqi [2 ]
Peng, Shiguang [2 ]
He, Yanling [2 ]
Wang, Tianyou [1 ]
机构
[1] Capital Med Univ, Beijing Childrens Hosp, Dept Hematol & Oncol, 56 Nanlishi Rd, Beijing 100045, Peoples R China
[2] Capital Med Univ, Beijing Chao Yang Hosp, Dept Dermatol, 8 Gongtinan Rd, Beijing 100020, Peoples R China
关键词
hemophagocytic lymphohistiocytosis; infectious mononucleosis; angioimmunoblastic T cell lymphoma; drug eruption; CLINICAL-FEATURES; ADULT PATIENTS; EXPRESSION; MANIFESTATIONS; ASSAY; EBV; DNA;
D O I
10.3892/etm.2018.6420
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Angioimmunoblastic T cell lymphoma (AITL)-associated hemophagocytic lymphohistiocytosis (HLH) rarely occurs with annular erythema multiforme-like rashes. The present case report describes a patient who was misdiagnosed with erythema multiforme at an early stage of the disease due to annular erythema multiforme-like eruptions. However, antihistamine treatment was ineffective. The patient progressed rapidly with high fever, hepatosplenomegaly and pharyngitis. The number of copies of Epstein-Barr virus DNA continuously increased. Accompanied by the swelling of lymph nodes, the blood cell count decreased. Further bone-marrow examination and biopsy of the lymph nodes were conducted. The patient was eventually diagnosed with AITL-associated HLH, and treated with etoposide together with cyclophosphamide, doxorubicin, vincristine and prednisolone. The patient was successfully treated with several courses of chemotherapy. In view of the fact that AITL-associated HLH with annular erythema multiforme-like rashes is relatively rare worldwide and is associated with a high mortality rate, the data on previous cases were reviewed with the hope of providing clinical bases for early diagnosis and treatment of AITL-associated HLH.
引用
收藏
页码:2060 / 2065
页数:6
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