Self-Assembled Wound Dressings Silence MMP-9 and Improve Diabetic Wound Healing In Vivo

被引：200

作者：

Castleberry, Steven A. ^{[1
,2
,3
,4
]}

Almquist, Benjamin D. ^{[1
,2
,3
]}

Li, Wei ^{[1
,2
]}

Reis, Tiago ^{[1
]}

Chow, John ^{[1
]}

Mayner, Sarah ^{[1
]}

Hammond, Paula T. ^{[1
,2
,3
]}

机构：

[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[2] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[3] MIT, Inst Soldier Nanotechnol, Cambridge, MA 02139 USA

[4] Harvard MIT Div Hlth Sci & Technol, Cambridge, MA 02139 USA

来源：

ADVANCED MATERIALS | 2016年 / 28卷 / 09期

基金：

美国国家卫生研究院;

关键词：

MATRIX-METALLOPROTEINASE INHIBITORS; FOOT ULCERS; MULTILAYER FILMS; STEM-CELL; SIRNA; MATRIX-METALLOPROTEINASE-9; DELIVERY; THERAPY; SKIN; EXPRESSION;

D O I：

10.1002/adma.201503565

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The direct local delivery of short interfering RNA (siRNA) into target tissues presents a real solution to several complex medical conditions that today lack efficacious therapies. The development of an ultrathin polymer coating is described to sustain the delivery of siRNA for up to 2 weeks in vitro and in vivo. This technology successfully reduces the expression of MMP-9 within the wounds of diabetic mice, significantly accelerating the wound healing process and improving the quality of tissue formed. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1809 / 1817

页数：9

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