Wnt pathway and breast cancer

被引：46
作者：
Mohinta, Sonia [1 ]
Wu, Hailong [1 ]
Chaurasia, Priyasri [1 ]
Watabe, Kounosuke [1 ]
机构：
[1] So Illinois Univ, Sch Med, Dept Med Microbiol Immunol & Cell Biol, Springfield, IL 62794 USA
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2007年 / 12卷
关键词：
Wnt; pathway; tumor; neoplasia; breast cancer; inhibitor; review;
D O I：
10.2741/2368
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Breast cancer is one of the most debilitating human carcinomas with second highest mortality rate after lung cancer in women. Recent advancement in genetic and biochemical analyses has deciphered the molecular pathways involved in breast cancer development. Wnt signal has long been established to play a critical role in normal development as well as in tumorigenesis. In this review, we summarize the role of Wnt signal in the development of mammary carcinoma, the molecular mechanism via which Wnt signal exerts its malignant potential and various nodal points in the Wnt cascade that can be targeted for drug development and cancer treatment.
引用
收藏
页码：4020 / 4033
页数：14
相关论文
共 152 条
[1]  
Abu-Jawdeh G, 1999, LAB INVEST, V79, P439
[2]   Gibberellins signal nuclear import of PHOR1, a photoperiod-responsive protein with homology to Drosophila armadillo [J].
Amador, V ;
Monte, E ;
García-Martínez, JL ;
Prat, S .
CELL, 2001, 106 (03) :343-354
[3]   Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism [J].
Ayyanan, A ;
Civenni, G ;
Ciarloni, L ;
Morel, C ;
Mueller, N ;
Lefort, K ;
Mandinova, A ;
Raffoul, W ;
Fiche, M ;
Dotto, GP ;
Brisken, C .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (10) :3799-3804
[4]  
Bànkfalvi A, 1999, HISTOPATHOLOGY, V34, P25
[5]   Functional interaction of beta-catenin with the transcription factor LEF-1 [J].
Behrens, J ;
vonKries, JP ;
Kuhl, M ;
Bruhn, L ;
Wedlich, D ;
Grosschedl, R ;
Birchmeier, W .
NATURE, 1996, 382 (6592) :638-642
[6]  
Benhaj K, 2006, ONCOL REP, V15, P701
[7]   A new member of the frizzled family from Drosophila functions as a Wingless receptor [J].
Bhanot, P ;
Brink, M ;
Samos, CH ;
Hsieh, JC ;
Wang, YS ;
Macke, JP ;
Andrew, D ;
Nathans, J ;
Nusse, R .
NATURE, 1996, 382 (6588) :225-230
[8]   High bone density due to a mutation in LDL-receptor-related protein 5 [J].
Boyden, LM ;
Mao, JH ;
Belsky, J ;
Mitzner, L ;
Farhi, A ;
Mitnick, MA ;
Wu, DQ ;
Insogna, K ;
Lifton, RP .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (20) :1513-1521
[9]   WNT-4 EXPRESSION INDUCES A PREGNANCY-LIKE GROWTH-PATTERN IN RECONSTITUTED MAMMARY-GLANDS IN VIRGIN MICE [J].
BRADBURY, JM ;
EDWARDS, PAW ;
NIEMEYER, CC ;
DALE, TC .
DEVELOPMENTAL BIOLOGY, 1995, 170 (02) :553-563
[10]  
Brisken C, 2000, GENE DEV, V14, P650
12345678910