The Role of Ageing and Parenchymal Senescence on Macrophage Function and Fibrosis

被引：25

作者：

Campbell, Ross A. ^{[1
]}

Docherty, Marie-Helena ^{[1
,2
]}

Ferenbach, David A. ^{[1
,2
]}

Mylonas, Katie J. ^{[1
]}

机构：

[1] Univ Edinburgh, Queens Med Res Inst, Ctr Inflammat Res, Edinburgh, Midlothian, Scotland

[2] Royal Infirm Edinburgh NHS Trust, Dept Renal Med, Edinburgh, Midlothian, Scotland

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷

基金：

英国惠康基金;

关键词：

macrophage; senescence; ageing; fibrosis; immunoageing; immunevasion; senolytic; senescence-associated secretory phenotype; CHRONIC KIDNEY-DISEASE; CELLULAR SENESCENCE; CALORIE RESTRICTION; BETA-GALACTOSIDASE; EPITHELIAL-CELLS; TISSUE-REPAIR; KNOCKOUT MICE; AGE; CLEARANCE; EXPRESSION;

D O I：

10.3389/fimmu.2021.700790

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this review, we examine senescent cells and the overlap between the direct biological impact of senescence and the indirect impact senescence has via its effects on other cell types, particularly the macrophage. The canonical roles of macrophages in cell clearance and in other physiological functions are discussed with reference to their functions in diseases of the kidney and other organs. We also explore the translational potential of different approaches based around the macrophage in future interventions to target senescent cells, with the goal of preventing or reversing pathologies driven or contributed to in part by senescent cell load in vivo.

引用

页数：16

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