Evolution of substrate specificities in the P-type ATPase superfamily

被引：754
作者：
Axelsen, KB
Palmgren, MG
机构：
[1] Univ Copenhagen, Inst Mol Biol, Dept Plant Physiol, DK-1353 Copenhagen K, Denmark
[2] Royal Vet & Agr Univ, Dept Plant Biol, DK-1871 Frederiksberg, Denmark
来源：
JOURNAL OF MOLECULAR EVOLUTION | 1998年 / 46卷 / 01期
关键词：
Na+; K+; Cu2+; H+; Mg2+; Cd2+; phospholipid translocases;
D O I：
10.1007/PL00006286
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
P-type ATPases make up a large superfamily of ATP-driven pumps involved in the transmembrane transport of charged substrates. We have performed an analysis of conserved core sequences in 159 P-type ATPases. The various ATPases group together in five major branches according to substrate specificity, and not according to the evolutionary relationship of the parental species, indicating that invention of new substrate specificities is accompanied by abrupt changes in the rate of sequence evolution. A hitherto-unrecognized family of P-type ATPases has been identified that is expected to be represented in all the major phyla of eukarya.
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收藏
页码：84 / 101
页数：18
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