Global efforts toward the cure of childhood acute lymphoblastic leukaemia

被引：97

作者：

Pui, Ching-Hon ^{[1
]}

Yang, Jun J. ^{[2
]}

Bhakta, Nickhill ^{[3
]}

Rodriguez-Galindo, Carlos ^{[3
]}

机构：

[1] Univ Tennessee, Hlth Sci Ctr, St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN USA

[2] Univ Tennessee, Hlth Sci Ctr, St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN USA

[3] Univ Tennessee, Hlth Sci Ctr, St Jude Childrens Res Hosp, Dept Global Pediat Med, Memphis, TN USA

来源：

LANCET CHILD & ADOLESCENT HEALTH | 2018年 / 2卷 / 06期

基金：

美国国家卫生研究院;

关键词：

MINIMAL RESIDUAL DISEASE; MIDDLE-INCOME COUNTRIES; ESSENTIAL MEDICINES; COST-EFFECTIVENESS; INDUCTION FAILURE; CENTRAL-AMERICA; CANCER CONTROL; DOWN-SYNDROME; YOUNG-PEOPLE; OPEN-LABEL;

D O I：

10.1016/S2352-4642(18)30066-X

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Improvements in risk-directed treatment and supportive care, together with increased reliance on both national and international collaborative studies, have made childhood acute lymphoblastic leukaemia (ALL) one of the most curable human cancers. Next-generation sequencing studies of leukaemia cells and the host germline provide new opportunities for precision medicine and thus potential improvements in the cure rate and quality of life of patients. Efforts are underway to assess the global impact of childhood ALL and develop initiatives that can meet the longterm challenge of providing quality care to children with this disease worldwide and improving cure rates globally. This ambitious task will rely on increased collaborative research and international networking so that the therapeutic gains in high-income countries can be translated to patients in low-income and middle-income countries. Ultimately, the greatest obstacle to overcome will be to fully understand leukaemogenesis, enabling measures to decrease the risk of leukaemia development and thus close the last major gap in offering a cure to any child who might have the disease.

引用

页码：440 / 454

页数：15

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