The immune network in thyroid cancer

被引：105
作者：
Galdiero, Maria Rosaria [1 ]
Varricchi, Gilda [1 ]
Marone, Gianni [1 ,2 ]
机构：
[1] Univ Naples Federico II, Sch Med, Dept Translat Med Sci DiSMeT, Naples, Italy
[2] CNR, Inst Expt Endocrinol & Oncol Gaetano Salvatore IE, Naples, Italy
来源：
ONCOIMMUNOLOGY | 2016年 / 5卷 / 06期
关键词：
Angiogenesis; chemokines; CXCL8/IL-8; dendritic cells; lymphangiogenesis; macrophages; mast cells; neutrophils; thyroid cancer; T reg cells; TUMOR-ASSOCIATED MACROPHAGES; ENDOTHELIAL GROWTH-FACTORS; REGULATORY T-CELLS; DENDRITIC CELLS; NK CELLS; MESENCHYMAL TRANSITION; AUTOCRINE PRODUCTION; PAPILLARY CARCINOMA; AGGRESSIVE FEATURES; CHEMOKINE CXCL10;
D O I：
10.1080/2162402X.2016.1168556
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The immune system plays critical roles in tumor prevention, but also in its initiation and progression. Tumors are subjected to immunosurveillance, but cancer cells generate an immunosuppressive microenvironment that favors their escape from immune-mediated elimination. During chronic inflammation, immune cells can contribute to the formation and progression of tumors by producing mitogenic, prosurvival, proangiogenic and lymphangiogenic factors. Thyroid cancer is the most frequent type of endocrine neoplasia and is the most rapidly increasing cancer in the US. In this review, we discuss recent findings on how different immune cells and mediators can contribute to thyroid cancer development and progression.
引用
收藏
页数：11
相关论文
共 117 条
  • [11] Nuclear Factor κB-Dependent Regulation of Angiogenesis, and Metastasis in an In Vivo Model of Thyroid Cancer Is Associated With Secreted Interleukin-8
    Bauerle, Kevin T.
    Schweppe, Rebecca E.
    Lund, Gregory
    Kotnis, Gregory
    Deep, Gagan
    Agarwal, Rajesh
    Pozdeyev, Nikita
    Wood, William M.
    Haugen, Bryan R.
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2014, 99 (08) : E1436 - E1444
  • [12] Ben Efraim AHN, 2014, CHEM IMMUNOL ALLERGY, V99, P138, DOI 10.1159/000353251
  • [13] Preoperative hematologic markers as independent predictors of prognosis in resected pancreatic ductal adenocarcinoma: neutrophil-lymphocyte versus platelet-lymphocyte ratio
    Bhatti, Imran
    Peacock, Oliver
    Lloyd, Gareth
    Larvin, Michael
    Hall, Richard I.
    [J]. AMERICAN JOURNAL OF SURGERY, 2010, 200 (02) : 197 - 203
  • [14] Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
    Bissell, Mina J.
    Hines, William C.
    [J]. NATURE MEDICINE, 2011, 17 (03) : 320 - 329
  • [15] Induction of a proinflammatory program in normal human thyrocytes by the RET/PTC1 oncogene
    Borrello, MG
    Alberti, L
    Fischer, A
    Degl'Innocenti, D
    Ferrario, C
    Gariboldi, M
    Marchesi, F
    Allavena, P
    Greco, A
    Collini, P
    Pilotti, S
    Cassinelli, G
    Bressan, P
    Fugazzola, L
    Mantovani, A
    Pierotti, MA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (41) : 14825 - 14830
  • [16] Bosisio D, 2014, CHEM IMMUNOL ALLERGY, V99, P89, DOI 10.1159/000353317
  • [17] The Proangiogenic Phenotype of Natural Killer Cells in Patients with Non-Small Cell Lung Cancer
    Bruno, Antonino
    Focaccetti, Chiara
    Pagani, Arianna
    Imperatori, Andrea S.
    Spagnoletti, Marco
    Rotolo, Nicola
    Cantelmo, Anna Rita
    Franzi, Francesca
    Capella, Carlo
    Ferlazzo, Guido
    Mortara, Lorenzo
    Albini, Adriana
    Noonan, Douglas M.
    [J]. NEOPLASIA, 2013, 15 (02): : 133 - U191
  • [18] Tumor-Associated Macrophages (TAMs) Form an Interconnected Cellular Supportive Network in Anaplastic Thyroid Carcinoma
    Caillou, Bernard
    Talbot, Monique
    Weyemi, Urbain
    Pioche-Durieu, Catherine
    Al Ghuzlan, Abir
    Bidart, Jean Michel
    Chouaib, Salem
    Schlumberger, Martin
    Dupuy, Corinne
    [J]. PLOS ONE, 2011, 6 (07):
  • [19] Thyroid Cancer
    Carling, Tobias
    Udelsman, Robert
    [J]. ANNUAL REVIEW OF MEDICINE, VOL 65, 2014, 65 : 125 - 137
  • [20] Expression of Decoy Receptor 3 in Diffuse Sclerosing Variant of Papillary Thyroid Carcinoma: Correlation with M2 Macrophage Differentiation and Lymphatic Invasion
    Chang, Wei-Chin
    Chen, Jui-Yu
    Lee, Chen-Hsen
    Yang, An-Hang
    [J]. THYROID, 2013, 23 (06) : 720 - 726
12345678910