The immune network in thyroid cancer

被引：105
作者：
Galdiero, Maria Rosaria [1 ]
Varricchi, Gilda [1 ]
Marone, Gianni [1 ,2 ]
机构：
[1] Univ Naples Federico II, Sch Med, Dept Translat Med Sci DiSMeT, Naples, Italy
[2] CNR, Inst Expt Endocrinol & Oncol Gaetano Salvatore IE, Naples, Italy
来源：
ONCOIMMUNOLOGY | 2016年 / 5卷 / 06期
关键词：
Angiogenesis; chemokines; CXCL8/IL-8; dendritic cells; lymphangiogenesis; macrophages; mast cells; neutrophils; thyroid cancer; T reg cells; TUMOR-ASSOCIATED MACROPHAGES; ENDOTHELIAL GROWTH-FACTORS; REGULATORY T-CELLS; DENDRITIC CELLS; NK CELLS; MESENCHYMAL TRANSITION; AUTOCRINE PRODUCTION; PAPILLARY CARCINOMA; AGGRESSIVE FEATURES; CHEMOKINE CXCL10;
D O I：
10.1080/2162402X.2016.1168556
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The immune system plays critical roles in tumor prevention, but also in its initiation and progression. Tumors are subjected to immunosurveillance, but cancer cells generate an immunosuppressive microenvironment that favors their escape from immune-mediated elimination. During chronic inflammation, immune cells can contribute to the formation and progression of tumors by producing mitogenic, prosurvival, proangiogenic and lymphangiogenic factors. Thyroid cancer is the most frequent type of endocrine neoplasia and is the most rapidly increasing cancer in the US. In this review, we discuss recent findings on how different immune cells and mediators can contribute to thyroid cancer development and progression.
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页数：11
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