Topographical Distribution of Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex

被引：11

作者：

Ellingson, Benjamin M. ^{[1
,2
]}

Hirata, Yoko ^{[1
,3
]}

Yogi, Akira ^{[1
,4
]}

Karavaeva, Elena ^{[1
]}

Leu, Kevin ^{[1
,2
]}

Woodworth, Davis C. ^{[1
,5
]}

Harris, Robert J. ^{[1
,5
]}

Enzmann, Dieter R. ^{[1
]}

Wu, Joyce Y. ^{[6
]}

Mathern, Gary W. ^{[7
]}

Salamon, Noriko ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiol Sci, 924 Westwood Blvd,Ste 615, Los Angeles, CA 90024 USA

[2] Univ Calif Los Angeles, Henry Samueli Sch Engn & Appl Sci, Dept Bioengn, Los Angeles, CA 90024 USA

[3] Toho Univ, Ohashi Med Ctr, Dept Neurosurg, Tokyo, Japan

[4] Univ Ryukyus, Grad Sch Med Sci, Dept Radiol, Okinawa, Japan

[5] Univ Calif Los Angeles, David Geffen Sch Med, Dept Biomed Phys, Los Angeles, CA 90024 USA

[6] Univ Calif Los Angeles, David Geffen Sch Med, Div Pediat Neurol, Dept Pediat, Los Angeles, CA 90024 USA

[7] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurosurg & Psychiat & Biobehav Med, Los Angeles, CA 90024 USA

来源：

JOURNAL OF CHILD NEUROLOGY | 2016年 / 31卷 / 05期

关键词：

tuberous sclerosis complex; population maps; analysis of differential involvement; seizures; epilepsy; topographic mapping; EPILEPSY SURGERY; CONSENSUS CONFERENCE; INFANTILE SPASMS; AUTISM; SEIZURE; SEVERITY; LOCATION; GENETICS; CHILDREN;

D O I：

10.1177/0883073815609151

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Tuberous sclerosis complex is a multisystem genetic syndrome often affecting the central nervous system. The purpose of the current study was to identify topographical patterns in the distribution specific to epileptogenic (n = 37) and nonepileptogenic (n = 544) tubers throughout the brain for a cohort of 23 tuberous sclerosis complex patients with a history of seizures. Tubers localized to the inferior parietal lobes, middle frontal lobes, middle temporal lobes, or central sulcus regions were associated with a high frequency of epileptogenic tubers. Epileptogenic tubers occurred statistically more frequently within the inferior parietal lobe and within the central sulcus region in children younger than 1 or between 1 and 3 years old, respectively. Results imply seizure activity in tuberous sclerosis complex patients can be associated with the location of cortical tubers.

引用

页码：636 / 645

页数：10

共 49 条

[1] Autism in tuberous sclerosis complex is related to both cortical and subcortical dysfunction [J].