Wide Variation in the Multiplicity of HIV-1 Infection among Injection Drug Users

被引：155

作者：

Bar, Katharine J. ^{[1
]}

Li, Hui ^{[1
]}

Chamberland, Annie ^{[2
]}

Tremblay, Cecile ^{[3
]}

Routy, Jean Pierre ^{[4
,5
]}

Grayson, Truman ^{[1
]}

Sun, Chuanxi ^{[1
]}

Wang, Shuyi ^{[1
]}

Learn, Gerald H. ^{[1
]}

Morgan, Charity J. ^{[1
]}

Schumacher, Joseph E. ^{[1
]}

Haynes, Barton F. ^{[6
]}

Keele, Brandon F. ^{[7
]}

Hahn, Beatrice H. ^{[1
]}

Shaw, George M. ^{[1
]}

机构：

[1] Univ Alabama, Birmingham, AL 35294 USA

[2] CHUM, Ctr Rech, Montreal, PQ, Canada

[3] Univ Montreal, Montreal, PQ, Canada

[4] McGill Univ, Ctr Hlth, Immunodeficiency Serv, Montreal, PQ, Canada

[5] McGill Univ, Ctr Hlth, Div Hematol, Montreal, PQ, Canada

[6] Duke Univ, Med Ctr, Durham, NC 27710 USA

[7] NCI, SAIC Frederick, Frederick, MD 21701 USA

来源：

JOURNAL OF VIROLOGY | 2010年 / 84卷 / 12期

基金：

美国国家卫生研究院; 加拿大健康研究院; 比尔及梅琳达.盖茨基金会;

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; COCAINE CO-USE; SELECTIVE TRANSMISSION; RHESUS MACAQUES; MONTREAL; DIVERSITY; VARIANTS; VACCINE; TRIAL; RISK;

D O I：

10.1128/JVI.00077-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Recent studies indicate that sexual transmission of human immunodeficiency virus type 1 (HIV-1) generally results from productive infection by only one virus, a finding attributable to the mucosal barrier. Surprisingly, a recent study of injection drug users (IDUs) from St. Petersburg, Russia, also found most subjects to be acutely infected by a single virus. Here, we show by single-genome amplification and sequencing in a different IDU cohort that 60% of IDU subjects were infected by more than one virus, including one subject who was acutely infected by at least 16 viruses. Multivariant transmission was more common in IDUs than in heterosexuals (60% versus 19%; odds ratio, 6.14; 95% confidence interval [CI], 1.37 to 31.27; P = 0.008). These findings highlight the diversity in HIV-1 infection risks among different IDU cohorts and the challenges faced by vaccines in protecting against this mode of infection.

引用

页码：6241 / 6247

页数：7

共 48 条

[1] Quantitating the Multiplicity of Infection with Human Immunodeficiency Virus Type 1 Subtype C Reveals a Non-Poisson Distribution of Transmitted Variants [J].

Abrahams, M. -R. ;

Anderson, J. A. ;

Giorgi, E. E. ;

Seoighe, C. ;

Mlisana, K. ;

Ping, L. -H. ;

Athreya, G. S. ;

Treurnicht, F. K. ;

Keele, B. F. ;

Wood, N. ;

Salazar-Gonzalez, J. F. ;

Bhattacharya, T. ;

Chu, H. ;

Hoffman, I. ;

Galvin, S. ;

Mapanje, C. ;

Kazembe, P. ;

Thebus, R. ;

Fiscus, S. ;

Hide, W. ;

Cohen, M. S. ;

Karim, S. Abdool ;

Haynes, B. F. ;

Shaw, G. M. ;

Hahn, B. H. ;

Korber, B. T. ;

Swanstrom, R. ;

Williamson, C. .

JOURNAL OF VIROLOGY, 2009, 83 (08) :3556-3567

[2] Global overview of injecting drug use and HIV infection among injecting drug users [J].

Aceijas, C ;

Stimson, GV ;

Hickman, M ;

Rhodes, T .

AIDS, 2004, 18 (17) :2295-2303

[3]

[Anonymous], 2008, REP GLOB AIDS EP

[4] Risk of HIV-1 transmission for parenteral exposure and blood transfusion: a systematic review and meta-analysis [J].

Baggaley, RF ;

Boily, MC ;

White, RG ;

Alary, M .

AIDS, 2006, 20 (06) :805-812

[5] Risk behaviour change and HIV infection among injection drug users in Montreal [J].

Brogly, SB ;

Bruneau, J ;

Vincelette, J ;

Lamothe, F ;

Franco, EL .

AIDS, 2000, 14 (16) :2575-2582

[6]

Bruneau J, 1997, AM J EPIDEMIOL, V146, P994, DOI 10.1093/oxfordjournals.aje.a009240

[7] Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission [J].

Derdeyn, CA ;

Decker, JM ;

Bibollet-Ruche, F ;

Mokili, JL ;

Muldoon, M ;

Denham, SA ;

Heil, ML ;

Kasolo, F ;

Musonda, R ;

Hahn, BH ;

Shaw, GM ;

Korber, BT ;

Allen, S ;

Hunter, E .

SCIENCE, 2004, 303 (5666) :2019-2022

[8] HIV Vaccine Trial Results - An Opening for Further Research [J].

Dolin, Raphael .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (23) :2279-2280

[9] Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection [J].

Fiebig, EW ;

Wright, DJ ;

Rawal, BD ;

Garrett, PE ;

Schumacher, RT ;

Peddada, L ;

Heldebrant, C ;

Smith, R ;

Conrad, A ;

Kleinman, SH ;

Busch, MP .

AIDS, 2003, 17 (13) :1871-1879

[10] Illicit opiold use in Canada:: Comparing social, health, and drug use characteristics of untreated users in five cities (OPICAN study) [J].

Fischer, B ;

Rehm, J ;

Brissette, S ;

Brochu, S ;

Bruneau, J ;

El-Guebaly, N ;

Noël, L ;

Tyndall, M ;

Wild, C ;

Mun, P ;

Baliunas, D .

JOURNAL OF URBAN HEALTH-BULLETIN OF THE NEW YORK ACADEMY OF MEDICINE, 2005, 82 (02) :250-266

← 1 2 3 4 5 →