I2 catalyzed tandem protocol for synthesis of quinoxalines via sp3, sp2 and sp C-H functionalization

被引：65

作者：

Vadagaonkar, Kamlesh S. ^{[1
]}

Kalmode, Hanuman P. ^{[1
]}

Murugan, Kaliyappan ^{[2
]}

Chaskar, Atul C. ^{[1
,3
]}

机构：

[1] Inst Chem Technol, Dept Dyestuff Technol, Bombay 400019, Maharashtra, India

[2] Natl Taiwan Univ, Taipei 10617, Taiwan

[3] Univ Mumbai, Natl Ctr Nanosci & Nanotechnol, Mumbai 400098, Maharashtra, India

来源：

RSC ADVANCES | 2015年 / 5卷 / 08期

关键词：

ONE-POT SYNTHESIS; ALPHA-HYDROXY KETONES; SOLID-PHASE SYNTHESIS; O-PHENYLENEDIAMINES; OXIDATION PROCESSES; BIOLOGICAL-ACTIVITY; EFFICIENT CATALYST; AEROBIC OXIDATION; HIGHLY EFFICIENT; DERIVATIVES;

D O I：

10.1039/c4ra08589b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

One-pot, atom-economic synthesis of quinoxalines has been achieved through generation of arylglyoxal from easily available ethylarenes, ethylenearenes and ethynearenes, and subsequent condensation with o-phenylenediamines. Catalytic I-2 with TBHP as an oxidant in DMSO is the system of choice for this domino reaction involving C-H functionalization/oxidative cyclization. This metal-free, mechanistically distinct and functional group tolerant tandem approach could be a powerful complement to traditional approaches for the synthesis of quinoxalines.

引用

页码：5580 / 5590

页数：11