Technological Development of Hydroalcoholic Extractive Solutions from Calendula officinalis L. Flowers by using Factorial Design

"Technological Development of Hydroalcoholic Extractive Solutions from Calendula officinalis L. Flowers by using Factorial Design". The work aimed at the development of extractive solutions from the flowers of Calendula officinalis, through maceration (MAC) and turbo-extraction (TURB) processes, employing the 32 (two factors and three levels) factorial design, in order to evaluate the influence of the time (MAC = 5, 10 and 15 days; TURB = 5, 15 and 25 min) and of the plant: solvent ratio (2.5, 73 and 12.5%, w/v) on the flavonoid content and the dry residue yields in the extractive solutions. For the maceration process, the 12.5% (w/v) plant: solvent ratio over 15 days were the best conditions to achieve the highest flavonoid content, in the turbo-extraction process the same performance was achieved in 5 min. For both processes the dry residue was proportional to the plant: solvent ratio.