Aminolysis of Epoxides in a Microreactor System: A Continuous Flow Approach to β-Amino Alcohols

被引：121
作者：
Bedore, Matthew W. [2 ]
Zaborenko, Nikolay [1 ]
Jensen, Klavs F. [1 ]
Jamison, Timothy F. [2 ]
机构：
[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA
[2] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2010年 / 14卷 / 02期
关键词：
CHEMOSELECTIVE ADDITION; REUSABLE CATALYST; HIGHLY EFFICIENT; SCALE-UP; MICROWAVE; ROUTE; MILD;
D O I：
10.1021/op9003136
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The use of a continuous flow microreactor for beta-amino alcohol formation by epoxide aminolysis is evaluated. Comparison to microwave batch reactions reveals that conditions obtainable in the microreactor can match or improve yields in many eases. By increasing the pressure of the system, maximum temperatures can also exceed those accessible using a microwave unit. The use of a microreactor for epoxide aminolysis reactions in the synthesis of two pharmaceutical relevant compounds is described.
引用
收藏
页码：432 / 440
页数：9
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