Revealing correlated amino acid positions in the DNA-binding regions of the CREB and AP-1 transcription factor families

被引：0

作者：

Afonnikov, DA ^{[1
]}

Kondrakhin, YV ^{[1
]}

Titov, II ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Cytol & Genet, Siberian Divv, Novosibirsk 630090, Russia

来源：

MOLECULAR BIOLOGY | 1997年 / 31卷 / 04期

关键词：

multiple alignment; transcription factor; bZIP domain; pair correlations; amino acid physicochemical properties; isoelectric point;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A method is proposed for analyzing multiple alignments of amino acid sequences to reveal pairs of positions for residues with correlated physicochemical properties. The technique estimates the direct dependence within the pair, eliminating the influence of other residues. Examination of the DNA-binding regions in the CREB and AP-1 transcription factor families demonstrates a negative correlation of isoelectric points for the N- and the C-flanking positions. The observed pattern is interpreted within the framework of a simplified electrostatic model of DNA-protein interaction.

引用

页码：631 / 637

页数：7

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