Tuberculosis research update

被引：12
作者：
Hanekom, W. A. [1 ]
Lawn, S. D. [2 ,3 ]
Dheda, K. [4 ,5 ]
Whitelaw, A. [6 ,7 ]
机构：
[1] Univ Cape Town, S African TB Vaccine Initiat, ZA-7925 Cape Town, South Africa
[2] Univ Cape Town, Desmond Tutu HIV Ctr, ZA-7925 Cape Town, South Africa
[3] London Sch Hyg & Trop Med, Clin Res Unit, London WC1, England
[4] Univ Cape Town, Lung Infect & Immun Unit, ZA-7925 Cape Town, South Africa
[5] UCL, Ctr Infect Dis & Int Hlth, London, England
[6] Univ Cape Town, Div Med Microbiol, ZA-7925 Cape Town, South Africa
[7] Natl Hlth Lab Serv, Cape Town, South Africa
来源：
TROPICAL MEDICINE & INTERNATIONAL HEALTH | 2010年 / 15卷 / 08期
基金：
英国惠康基金; 新加坡国家研究基金会; 美国国家卫生研究院; 英国医学研究理事会;
关键词：
tuberculosis; vaccine; drug resistance; HIV; diagnosis; MULTIDRUG-RESISTANT TUBERCULOSIS; RECONSTITUTION INFLAMMATORY SYNDROME; MYCOBACTERIUM-TUBERCULOSIS; IMMUNE RECONSTITUTION; ANTIRETROVIRAL THERAPY; MICROSCOPIC-OBSERVATION; ACTIVE TUBERCULOSIS; VACCINE DEVELOPMENT; SOUTH-AFRICA; RISK-FACTORS;
D O I：
10.1111/j.1365-3156.2010.02568.x
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Tuberculosis (TB) remains a major challenge to global public health in the 21st century. In 2007, there were an estimated 9.27 million new cases and 1.3 million deaths among HIV-negative patients with TB. The HIV-associated TB epidemic, drug-resistant disease, the need for better diagnostic assays and the limited efficacy of Bacille Calmette-Guerin vaccination are four important obstacles to further progress in global TB control. In this brief review, we provide a focused update on these four key areas of TB research.
引用
收藏
页码：981 / 989
页数：9
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