The role of ionic strength on the enhancement of the hemolytic activity of sticholysin I, a cytolysin from Stichodactyla helianthus

被引：15

作者：

Alvarez, C

Lanio, ME

Tejuca, M

Martínez, D

Pazos, F

Campos, AM

Encinas, MV

Pertinhez, T

Schreier, S

Lissi, EA

机构：

[1] Univ Santiago Chile, Fac Quim & Biol, Dept Quim, Santiago, Chile

[2] Univ La Habana, Fac Biol, Dept Bioquim, La Habana, Cuba

[3] Univ Sao Paulo, Inst Quim, Dept Bioquim, Lab Biol Estrutural, BR-01498 Sao Paulo, Brazil

来源：

TOXICON | 1998年 / 36卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

D O I：

10.1016/S0041-0101(97)00069-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Sticholysin I (St I) is a potent cytolytic polypeptide purified from the Caribbean sea anemone Stichodactyla helianthus. The hemolytic activity of sticholysin is potentiated by its preincubation at high ionic strengths. In the present work the mechanism of the potentiating action of the medium ionic strength on the toxin hemolytic capacity is investigated. It is suggested that preincubation with high saline concentration induces a transition of St I to a more relaxed conformation that facilitates the lytic process. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：165 / 178

页数：14

共 32 条

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