KRAS-targeted therapies in advanced solid cancers: drug the undruggable?

被引：5

作者：

Saleh, Khalil ^{[1
]}

Kordahi, Manal ^{[2
]}

Felefly, Tony ^{[3
]}

Kourie, Hampig Raphael ^{[4
]}

Khalife, Nadine ^{[5
]}

机构：

[1] Gustave Roussy Canc Campus, Dept Hematol, F-94800 Villejuif, France

[2] Natl Inst Pathol, Dept Pathol, Baabda 1003, Lebanon

[3] St Joseph Univ, Sch Med, Dept Radiat Oncol, Hotel Dieu France Univ Hosp, Beirut 1100, Lebanon

[4] St Joseph Univ, Fac Med, Dept Hematol Oncol, Beirut 1100, Lebanon

[5] Gustave Roussy Canc Campus, Dept Med Oncol, F-94800 Villejuif, France

来源：

PHARMACOGENOMICS | 2021年 / 22卷 / 10期

关键词：

adagrasib; colorectal cancer; KRAS(G12C) mutations; non-small-cell lung cancer; RAS; sotorasib; KRYSTAL-1; ACTIVITY; ADAGRASIB MRTX849; SAFETY;

D O I：

10.2217/pgs-2021-0045

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

[No abstract available]

引用

页码：587 / 590

页数：4

共 20 条

[1] EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer
Amodio, Vito
Yaeger, Rona
Arcella, Pamela
Cancelliere, Carlotta
Lamba, Simona
Lorenzato, Annalisa
Arena, Sabrina
Montone, Monica
Mussolin, Benedetta
Bian, Yu
Whaley, Adele
Pinnelli, Marika
Murciano-Goroff, Yonina R.
Vakiani, Efsevia
Valeri, Nicola
Liao, Wei-Li
Bhalkikar, Anuja
Thyparambil, Sheeno
Zhao, Hui-Yong
de Stanchina, Elisa
Marsoni, Silvia
Siena, Salvatore
Bertotti, Andrea
Trusolino, Livio
Li, Bob T.
Rosen, Neal
Di Nicolantonio, Federica
Bardelli, Alberto
Misale, Sandra
[J]. CANCER DISCOVERY, 2020, 10 (08) : 1129 - 1139
[2] Comprehensive molecular characterization of human colon and rectal cancer
Muzny, Donna M.
Bainbridge, Matthew N.
Chang, Kyle
Dinh, Huyen H.
Drummond, Jennifer A.
Fowler, Gerald
Kovar, Christie L.
Lewis, Lora R.
Morgan, Margaret B.
Newsham, Irene F.
Reid, Jeffrey G.
Santibanez, Jireh
Shinbrot, Eve
Trevino, Lisa R.
Wu, Yuan-Qing
Wang, Min
Gunaratne, Preethi
Donehower, Lawrence A.
Creighton, Chad J.
Wheeler, David A.
Gibbs, Richard A.
Lawrence, Michael S.
Voet, Douglas
Jing, Rui
Cibulskis, Kristian
Sivachenko, Andrey
Stojanov, Petar
McKenna, Aaron
Lander, Eric S.
Gabriel, Stacey
Getz, Gad
Ding, Li
Fulton, Robert S.
Koboldt, Daniel C.
Wylie, Todd
Walker, Jason
Dooling, David J.
Fulton, Lucinda
Delehaunty, Kim D.
Fronick, Catrina C.
Demeter, Ryan
Mardis, Elaine R.
Wilson, Richard K.
Chu, Andy
Chun, Hye-Jung E.
Mungall, Andrew J.
Pleasance, Erin
Robertson, A. Gordon
Stoll, Dominik
Balasundaram, Miruna
[J]. NATURE, 2012, 487 (7407) : 330 - 337
[3] Cancer Genome Atlas Research Network, 2018, Nature, V559, pE12, DOI [10.1038/nature13385, 10.1038/s41586-018-0228-6]
[4] Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma
Aguirre, Andrew J.
Hruban, Ralph H.
Raphael, Benjamin J.
[J]. CANCER CELL, 2017, 32 (02) : 185 - +
[5] KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors
Hong, David S.
Fakih, Marwan G.
Strickler, John H.
Desai, Jayesh
Durm, Gregory A.
Shapiro, Geoffrey I.
Falchook, Gerald S.
Price, Timothy J.
Sacher, Adrian
Denlinger, Crystal S.
Bang, Yung-Jue
Dy, Grace K.
Krauss, John C.
Kuboki, Yasutoshi
Kuo, James C.
Coveler, Andrew L.
Park, Keunchil
Kim, Tae Won
Barlesi, Fabrice
Munster, Pamela N.
Ramalingam, Suresh S.
Burns, Timothy F.
Meric-Bernstam, Funda
Henary, Haby
Ngang, Jude
Ngarmchamnanrith, Gataree
Kim, June
Houk, Brett E.
Canon, Jude
Lipford, J. Russell
Friberg, Gregory
Lito, Piro
Govindan, Ramaswamy
Li, Bob T.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (13) : 1207 - 1217
[6] IASLC, SOT SHOWS EARL ACT K
[7] Jänne PA, 2020, EUR J CANCER, V138, pS1
[8] Johnson ML, 2020, EUR J CANCER, V138, pS2
[9] Specific mutations in KRAS codon 12 are associated with worse overall survival in patients with advanced and recurrent colorectal cancer
Jones, Robert P.
Sutton, Paul A.
Evans, Jonathan P.
Clifford, Rachel
McAvoy, Andrew
Lewis, James
Rousseau, Abigail
Mountford, Roger
McWhirter, Derek
Malik, Hassan Z.
[J]. BRITISH JOURNAL OF CANCER, 2017, 116 (07) : 923 - 929
[10] Mark Awad., AACR ANN M 2021 ONL

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