The in vivo effects of unloading and compression on T1-Gd (dGEMRIC) relaxation times in healthy articular knee cartilage at 3.0 Tesla

被引：32

作者：

Mayerhoefer, Marius E. ^{[1
]}

Welsch, Goetz H. ^{[1
,2
]}

Mamisch, Tallal C. ^{[3
]}

Kainberger, Franz ^{[1
]}

Weber, Michael ^{[1
]}

Nemec, Stefan ^{[1
]}

Friedrich, Klaus M. ^{[1
]}

Dirisamer, Albert ^{[1
]}

Trattnig, Siegfried ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Radiol, MR Ctr, A-1090 Vienna, Austria

[2] Univ Erlangen Nurnberg, Dept Trauma Surg, D-91054 Erlangen, Germany

[3] Univ Bern, Dept Orthopaed Surg, Inselspital, CH-3010 Bern, Switzerland

来源：

EUROPEAN RADIOLOGY | 2010年 / 20卷 / 02期

关键词：

Articular cartilage/disorders; MR imaging/diagnosis; 3T MR imaging; GADOLINIUM-ENHANCED MRI; HYALINE CARTILAGE; T-2; GLYCOSAMINOGLYCAN;

D O I：

10.1007/s00330-009-1559-3

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The purpose was to investigate the in vivo effects of unloading and compression on T1-Gd relaxation times in healthy articular knee cartilage. Ten volunteers were enrolled, and dGEMRIC images of their right knee joints were obtained using 3.0-T MR at three timepoints: directly following exercise ("baseline"), approximately 15 min after unloading ("unloading") and during application of a compressive force (50% of the body weight) generated by a loading device via a footplate ("compression"). Our analysis of variance of pooled data from all cartilage zones demonstrated a significant mean T1-Gd decrease of 56.6 ms between baseline and compression (p < 0.001), and a significant mean decrease of 42.1 ms between unloading and compression (p < 0.001). No significant difference was found between baseline and unloading. Higher mean T1-Gd values were observed in the cartilage contact zone (central femoral and tibial zones; 698.3 +/- 162.2 ms) than in the non-contact zone (anterior and posterior femoral and tibial zones, and dorsal femoral zone; 662.9 +/- 149.3 ms; p < 0.01). T1-Gd times appear to be sensitive to mechanical cartilage stress, and thus, further studies are warranted that investigate the relationship between the biochemical load response and the biomechanical properties of articular cartilage.

引用

页码：443 / 449

页数：7

共 27 条

[1] Glycosaminoglycan in articular cartilage: In vivo assessment with delayed Gd(DTPA)(2-)-enhanced MR imaging [J].

Bashir, A ;

Gray, ML ;

Boutin, RD ;

Burstein, D .

RADIOLOGY, 1997, 205 (02) :551-558

[2] Is MRI fulfilling its promise for molecular imaging of cartilage in arthritis? [J].

Burstein, D. ;

Gray, M. L. .

OSTEOARTHRITIS AND CARTILAGE, 2006, 14 (11) :1087-1090

[3]

Burstein D, 2001, MAGNET RESON MED, V45, P36, DOI 10.1002/1522-2594(200101)45:1<36::AID-MRM1006>3.0.CO

[4]

2-W

[5] Matrix fixed-charge density as determined by magnetic resonance microscopy of bioreactor-derived hyaline cartilage correlates with biochemical and biomechanical properties [J].

Chen, CT ;

Fishbein, KW ;

Torzilli, PA ;

Hilger, A ;

Spencer, RGS ;

Horton, WE .

ARTHRITIS AND RHEUMATISM, 2003, 48 (04) :1047-1056

[6] Is it important to secure the hems during lateral meniscal transplantation? A cadaveric study [J].

Chen, MI ;

Branch, TP ;

Hutton, WC .

ARTHROSCOPY, 1996, 12 (02) :174-181

[7]

Gründer W, 2000, MAGN RESON MED, V43, P884, DOI 10.1002/1522-2594(200006)43:6<884::AID-MRM15>3.0.CO

[8]

2-U

[9]

Heinegaard D, 2003, OSTEOARTHRITIS, P72

[10] In situ measurement of articular cartilage deformation in intact femoropatellar joints under static loading [J].

Herberhold, C ;

Faber, S ;

Stammberger, T ;

Steinlechner, M ;

Putz, R ;

Englmeier, KH ;

Reiser, M ;

Eckstein, F .

JOURNAL OF BIOMECHANICS, 1999, 32 (12) :1287-1295

← 1 2 3 →