IL-17 in Chronic Inflammation: From Discovery to Targeting

被引：348
作者：
Beringer, Audrey [1 ]
Noack, Melissa [1 ]
Miossec, Pierre [1 ]
机构：
[1] Univ Lyon, Dept Immunol & Rheumatol, Immunogen & Inflammat Res Unit, EA 4130, Lyon, France
来源：
TRENDS IN MOLECULAR MEDICINE | 2016年 / 22卷 / 03期
关键词：
ANTI-INTERLEUKIN-17A MONOCLONAL-ANTIBODY; NECROSIS-FACTOR-ALPHA; RHEUMATOID-ARTHRITIS; DOUBLE-BLIND; T-CELL; HOST-DEFENSE; PHASE-II; PSORIATIC-ARTHRITIS; MULTIPLE-SCLEROSIS; DISEASE-ACTIVITY;
D O I：
10.1016/j.molmed.2016.01.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Interleukin-17 (IL-17) is a cytokine which elicits protection against extracellular bacterial and fungal infections and which plays important roles in inflammation. However, when produced in excess, it contributes to chronic inflammation associated with many inflammatory and autoimmune disorders. This has made 1L-17 an attractive therapeutic target. The present review describes the structure of the IL-17 family, the IL-17 receptor complex, and the cells producing IL-17. The contributions of IL-17 to disease as well as new IL-17-based treatment options are discussed. Finally, the results of IL-17 or IL-17 receptor inhibitors in clinical trials are detailed. With a fruitful outlook, drug registration has now been granted for psoriasis psoriatic arthritis and ankylosing spondylitis, and also bears great potential in a growing number of conditions.
引用
收藏
页码：230 / 241
页数：12
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