The role of small vessel disease in development of Alzheimer's disease

被引:2
|
作者
Grau-Slevin, Marta [1 ,2 ]
Arboix, Adria [2 ]
Gaffney, John [1 ]
Slevin, Mark [1 ]
机构
[1] Manchester Metropolitan Univ, Sch Biol Chem & Hlth Sci, Manchester M1 5GD, Lancs, England
[2] Univ Barcelona, Hosp Univ Sagrat Cor, Dept Neurol, Cerebrovasc Div, Barcelona, Spain
关键词
Alzheimer's disease; small vessel disease; development; risk factors; diagnosis; neuroimaging studies; histopathological studies; neurodegenerative disease; neural regeneration; AMYLOID-BETA-PEPTIDE; MITOCHONDRIA DNA DELETIONS; TYPE-2; DIABETES-MELLITUS; INDEPENDENT RISK-FACTOR; WHITE-MATTER LESIONS; APOLIPOPROTEIN-E; COGNITIVE DECLINE; CEREBRAL MICROBLEEDS; BLOOD-PRESSURE; CEREBROVASCULAR DYSFUNCTION;
D O I
10.3969/j.issn.1673-5374.2010.04.012
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Classically Alzheimer's disease and vascular dementia have been considered as two different entities, with their own clinical criteria, but relatively recent epidemiological and clinicopathological studies suggest an overlap between them sharing not only most of the risk factors and some clinical aspects but also pathophysiological mechanisms. Cerebrovascular lesions, especially small vessel disease (lacunar infarcts, white matter hyperintensities and microbleeds), may magnify the effects of mild Alzheimer's disease pathology and promote the progression of cognitive decline and may also be a precursor of neuronal damage and dementia. "Vascular hypothesis" of Alzheimer's disease would open a window for new approaches and treatments.
引用
收藏
页码:310 / 320
页数:11
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