Glassy dynamics in models of confluent tissue with mitosis and apoptosis

被引:40
作者
Czajkowski, Michael [1 ]
Sussman, Daniel M. [2 ,3 ]
Marchetti, M. Cristina [4 ]
Manning, M. Lisa [2 ,3 ]
机构
[1] Georgia Inst Technol, Phys Dept, Atlanta, GA 30332 USA
[2] Syracuse Univ, Dept Phys, Syracuse, NY 13244 USA
[3] Syracuse Univ, BioInspired Inst, Syracuse, NY 13244 USA
[4] Univ Calif Santa Barbara, Dept Phys, Santa Barbara, CA 93106 USA
关键词
CELL-MIGRATION; ELASTIC FIELD; PROLIFERATION; TRANSITIONS; MECHANICS; DIVISION; BEHAVIOR;
D O I
10.1039/c9sm00916g
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Recent work on particle-based models of tissues has suggested that any finite rate of cell division and cell death is sufficient to fluidize an epithelial tissue. At the same time, experimental evidence has indicated the existence of glassy dynamics in some epithelial layers despite continued cell cycling. To address this discrepancy, we quantify the role of cell birth and death on glassy states in confluent tissues using simulations of an active vertex model that includes cell motility, cell division, and cell death. Our simulation data is consistent with a simple ansatz in which the rate of cell-life cycling and the rate of relaxation of the tissue in the absence of cell cycling contribute independently and additively to the overall rate of cell motion. Specifically, we find that a glass-like regime with caging behavior indicated by subdiffusive cell displacements can be achieved in systems with sufficiently low rates of cell cycling.
引用
收藏
页码:9133 / 9149
页数:17
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